413 Article(s)Download |
PMID | Title | Pub. Year | #Total Relationships |
1 | 33853293 | Pevonedistat and azacitidine upregulate NOXA (PMAIP1) to increase sensitivity to venetoclax in preclinical models of acute myeloid leukemia. | 2022 Apr 1 | 1 |
2 | 34663943 | The manipulation of apoptosis for cancer therapy using BH3-mimetic drugs. | 2022 Jan | 1 |
3 | 35013156 | Pediatric multicellular tumor spheroid models illustrate a therapeutic potential by combining BH3 mimetics with Natural Killer (NK) cell-based immunotherapy. | 2022 Jan 10 | 1 |
4 | 35140891 | Structural insights into apoptotic regulation of human Bfk as a novel Bcl-2 family member. | 2022 | 1 |
5 | 35364607 | Maximal Activation of Apoptosis Signaling by Cotargeting Antiapoptotic Proteins in BH3 Mimetic-Resistant AML and AML Stem Cells. | 2022 Jun 1 | 2 |
6 | 35393436 | MEK and MCL-1 sequential inhibition synergize to enhance rhabdomyosarcoma treatment. | 2022 Apr 7 | 1 |
7 | 35411095 | JAK3 mutations and mitochondrial apoptosis resistance in T-cell acute lymphoblastic leukemia. | 2022 Jun | 1 |
8 | 35458468 | Structural Insight into KsBcl-2 Mediated Apoptosis Inhibition by Kaposi Sarcoma Associated Herpes Virus. | 2022 Mar 31 | 1 |
9 | 35598030 | Progress in understanding the mechanisms of resistance to BCL-2 inhibitors. | 2022 May 21 | 1 |
10 | 32079453 | Comparison of putative BH3 mimetics AT-101, HA14-1, sabutoclax and TW-37 with ABT-737 in platelets. | 2021 Jan 2 | 1 |
11 | 32790056 | Selective Covalent Targeting of Anti-apoptotic BFL-1 by a Sulfonium-Tethered Peptide. | 2021 Jan 15 | 1 |
12 | 33241675 | Inhibition of the anti-apoptotic protein MCL-1 severely suppresses human hematopoiesis | 2021 Dec 1 | 1 |
13 | 33259592 | Targeting Bfl-1 via acute CDK9 inhibition overcomes intrinsic BH3-mimetic resistance in lymphomas. | 2021 May 27 | 1 |
14 | 33494688 | Exploring the Mitochondrial Apoptotic Cell Death Landscape and Associated Components Serving as Molecular Targets, Primarily for Synthetic and Natural Drugs Targeting Oncology Therapeutics. | 2021 | 1 |
15 | 33549704 | Cancer cell death strategies by targeting Bcl-2's BH4 domain. | 2021 Apr | 1 |
16 | 33581643 | Targeting critical kinases and anti-apoptotic molecules overcomes steroid resistance in MLL-rearranged leukaemia. | 2021 Feb | 1 |
17 | 33785651 | Expanding the Repertoire for "Large Small Molecules": Prodrug ABBV-167 Efficiently Converts to Venetoclax with Reduced Food Effect in Healthy Volunteers. | 2021 Jun | 1 |
18 | 33785871 | Breast cancer dependence on MCL-1 is due to its canonical anti-apoptotic function. | 2021 Sep | 1 |
19 | 33806619 | Stroma-Mediated Resistance to S63845 and Venetoclax through MCL-1 and BCL-2 Expression Changes Induced by miR-193b-3p and miR-21-5p Dysregulation in Multiple Myeloma. | 2021 Mar 4 | 1 |
20 | 33824975 | Intact TP-53 function is essential for sustaining durable responses to BH3-mimetic drugs in leukemias. | 2021 May 20 | 1 |
21 | 33917026 | BH3 Mimetic Sensitivity of Colorectal Cancer Cell Lines in Correlation with Molecular Features Identifies Predictors of Response. | 2021 Apr 7 | 1 |
22 | 33925117 | Intrinsically Connected: Therapeutically Targeting the Cathepsin Proteases and the Bcl-2 Family of Protein Substrates as Co-regulators of Apoptosis. | 2021 Apr 28 | 1 |
23 | 33962088 | Structure-based design approach of potential BCL-2 inhibitors for cancer chemotherapy. | 2021 Jul | 1 |
24 | 34028739 | Methods for Studying Myofibroblast Apoptotic Pathways. | 2021 | 1 |
25 | 34117376 | BCL-XL is crucial for progression through the adenoma-to-carcinoma sequence of colorectal cancer. | 2021 Dec | 1 |
26 | 34174982 | Genomics of Resistance to Targeted Therapies. | 2021 Aug | 2 |
27 | 34257082 | Cell Line-Specific Network Models of ER+ Breast Cancer Identify Potential PI3Kα Inhibitor Resistance Mechanisms and Drug Combinations. | 2021 Sep 1 | 1 |
28 | 34257274 | Bcl-2/Bcl-xL inhibitor ABT-263 overcomes hypoxia-driven radioresistence and improves radiotherapy. | 2021 Jul 13 | 1 |
29 | 34315868 | Dynamic BH3 profiling identifies active BH3 mimetic combinations in non-small cell lung cancer. | 2021 Jul 27 | 1 |
30 | 34320168 | BCL2 and MCL1 inhibitors for hematologic malignancies. | 2021 Sep 30 | 1 |
31 | 34372579 | Structural Investigation of Orf Virus Bcl-2 Homolog ORFV125 Interactions with BH3-Motifs from BH3-Only Proteins Puma and Hrk. | 2021 Jul 15 | 2 |
32 | 34451846 | A Novel Regimen for Treating Melanoma: MCL1 Inhibitors and Azacitidine. | 2021 Jul 30 | 1 |
33 | 34478517 | Heterogeneous modulation of Bcl-2 family members and drug efflux mediate MCL-1 inhibitor resistance in multiple myeloma. | 2021 Oct 26 | 3 |
34 | 34493661 | Lipids modulate the BH3-independent membrane targeting and activation of BAX and Bcl-xL. | 2021 Sep 14 | 1 |
35 | 34548471 | ASXL1 mutations are associated with distinct epigenomic alterations that lead to sensitivity to venetoclax and azacytidine. | 2021 Sep 21 | 1 |
36 | 34638779 | B Cell Lymphoma 2: A Potential Therapeutic Target for Cancer Therapy. | 2021 Sep 28 | 1 |
37 | 34693118 | Designing BH3-Mimetic Peptide Inhibitors for the Viral Bcl-2 Homologues A179L and BHRF1: Importance of Long-Range Electrostatic Interactions. | 2021 Oct 19 | 1 |
38 | 34758330 | TIAM1-RAC1 promote small-cell lung cancer cell survival through antagonizing Nur77-induced BCL2 conformational change. | 2021 Nov 9 | 1 |
39 | 34781947 | Functional apoptosis profiling identifies MCL-1 and BCL-xL as prognostic markers and therapeutic targets in advanced thymomas and thymic carcinomas. | 2021 Nov 16 | 1 |
40 | 34926454 | Inhibition of the Anti-Apoptotic Bcl-2 Family by BH3 Mimetics Sensitize the Mitochondrial Permeability Transition Pore Through Bax and Bak. | 2021 | 1 |
41 | 34942200 | Expression Differences in BCL2 Family Members between Uveal and Cutaneous Melanomas Account for Varying Sensitivity to BH3 Mimetics. | 2021 Dec 20 | 2 |
42 | 31388792 | A phase I study of AT-101, a BH3 mimetic, in combination with paclitaxel and carboplatin in solid tumors. | 2020 Jun | 1 |
43 | 31669390 | Using CETSA assay and a mathematical model to reveal dual Bcl-2/Mcl-1 inhibition and on-target mechanism for ABT-199 and S1. | 2020 Jan 15 | 1 |
44 | 31880257 | Role of BCL-2 Family Proteins in Apoptosis and its Regulation by Nutrients. | 2020 | 2 |
45 | 32113682 | Low DEDD expression in breast cancer cells indicates higher sensitivity to the Bcl-2-specific inhibitor ABT-199. | 2020 May 7 | 2 |
46 | 32131385 | Targeting Mitochondrial Apoptosis to Overcome Treatment Resistance in Cancer. | 2020 Mar 2 | 1 |
47 | 32183335 | Restoring Apoptosis with BH3 Mimetics in Mature B-Cell Malignancies. | 2020 Mar 14 | 1 |
48 | 32203216 | A direct comparison of selective BH3-mimetics reveals BCL-XL, BCL-2 and MCL-1 as promising therapeutic targets in neuroblastoma. | 2020 May | 5 |
49 | 32247581 | Mcl-1 as a "barrier" in cancer treatment: Can we target it now? | 2020 | 1 |
50 | 32309275 | Competition Between Phenothiazines and BH3 Peptide for the Binding Site of the Antiapoptotic BCL-2 Protein. | 2020 | 1 |