Temozolomide

BCL2 associated X, apoptosis regulator ; Homo sapiens







17 Article(s)
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1 35278900 Tubeimoside-I sensitizes temozolomide-resistant glioblastoma cells to chemotherapy by reducing MGMT expression and suppressing EGFR induced PI3K/Akt/mTOR/NF-κB-mediated signaling pathway. 2022 Feb 27 1
2 33590411 Silencing of ZFP36L2 increases sensitivity to temozolomide through G2/M cell cycle arrest and BAX mediated apoptosis in GBM cells. 2021 Feb 2
3 30426452 LRRC8A potentiates temozolomide sensitivity in glioma cells via activating mitochondria-dependent apoptotic pathway. 2019 Jan 1
4 30446901 Lower expression of Bax predicts poor clinical outcome in patients with glioma after curative resection and radiotherapy/chemotherapy. 2019 Jan 1
5 30003979 Verapamil potentiates anti-glioblastoma efficacy of temozolomide by modulating apoptotic signaling. 2018 Oct 1
6 30217261 Honokiol enhances temozolomide-induced apoptotic insults to malignant glioma cells via an intrinsic mitochondrion-dependent pathway. 2018 Oct 1 1
7 30425242 Hypoxia-mediated mitochondria apoptosis inhibition induces temozolomide treatment resistance through miR-26a/Bad/Bax axis. 2018 Nov 13 3
8 27447864 Osteosarcoma cells with genetic signatures of BRCAness are susceptible to the PARP inhibitor talazoparib alone or in combination with chemotherapeutics. 2017 Jul 25 2
9 28599419 A conditionally replicating adenovirus expressing IL-24 acts synergistically with temozolomide to enhance apoptosis in melanoma cells in vitro. 2017 Jun 1
10 27669171 Reactive oxygen species contribute toward Smac mimetic/temozolomide-induced cell death in glioblastoma cells. 2016 Nov 2
11 27685789 FK228 augmented temozolomide sensitivity in human glioma cells by blocking PI3K/AKT/mTOR signal pathways. 2016 Dec 1
12 26188279 NVP-BEZ235, a novel dual PI3K-mTOR inhibitor displays anti-glioma activity and reduces chemoresistance to temozolomide in human glioma cells. 2015 Oct 10 1
13 26438158 PARP Inhibitors Sensitize Ewing Sarcoma Cells to Temozolomide-Induced Apoptosis via the Mitochondrial Pathway. 2015 Dec 1
14 22086271 LY294002 enhances cytotoxicity of temozolomide in glioma by down-regulation of the PI3K/Akt pathway. 2012 Feb 1
15 20633539 MiR-21 protected human glioblastoma U87MG cells from chemotherapeutic drug temozolomide induced apoptosis by decreasing Bax/Bcl-2 ratio and caspase-3 activity. 2010 Sep 17 4
16 20880848 Activation of AMP-activated protein kinase by temozolomide contributes to apoptosis in glioblastoma cells via p53 activation and mTORC1 inhibition. 2010 Dec 24 1
17 15588281 Dexamethasone protected human glioblastoma U87MG cells from temozolomide induced apoptosis by maintaining Bax:Bcl-2 ratio and preventing proteolytic activities. 2004 Dec 8 3