| 1 |
34558391 | KRAS G12C fragment screening renders new binding pockets. | 2022 Jan |
1 |
| 2 |
35267628 | Direct Targeting KRAS Mutation in Non-Small Cell Lung Cancer: Focus on Resistance. | 2022 Mar 4 |
1 |
| 3 |
35314814 | KRAS is vulnerable to reversible switch-II pocket engagement in cells. | 2022 Jun |
1 |
| 4 |
33309959 | Discoveries in the redox regulation of KRAS. | 2021 Feb |
1 |
| 5 |
33357178 | Facile Synthesis of Boc-Protected Selenocystine and its Compatibility with Late-Stage Farnesylation at Cysteine Site. | 2021 |
7 |
| 6 |
33774492 | Discovery of novel quinazoline-based covalent inhibitors of KRAS G12C with various cysteine-targeting warheads as potential anticancer agents. | 2021 May |
1 |
| 7 |
33977473 | Production and Membrane Binding of N-Terminally Acetylated, C-Terminally Farnesylated and Carboxymethylated KRAS4b. | 2021 |
1 |
| 8 |
34161704 | Acquired Resistance to KRASG12C Inhibition in Cancer. | 2021 Jun 24 |
2 |
| 9 |
34402302 | Tuning Cyclometalated Gold(III) for Cysteine Arylation and Ligand-Directed Bioconjugation. | 2021 Oct 4 |
1 |
| 10 |
29239694 | A novel prenyl-polybasic domain code determines lipid-binding specificity of the K-Ras membrane anchor. | 2020 May |
1 |
| 11 |
32176377 | Targeting Krasg12c -mutant cancer with a mutation-specific inhibitor. | 2020 Aug |
1 |
| 12 |
32250617 | Identification of the Clinical Development Candidate MRTX849, a Covalent KRASG12C Inhibitor for the Treatment of Cancer. | 2020 Jul 9 |
1 |
| 13 |
32414921 | Multivalent assembly of KRAS with the RAS-binding and cysteine-rich domains of CRAF on the membrane. | 2020 Jun 2 |
1 |
| 14 |
32869838 | Inhibition of RAS: proven and potential vulnerabilities. | 2020 Oct 30 |
1 |
| 15 |
30846362 | KRAS Prenylation Is Required for Bivalent Binding with Calmodulin in a Nucleotide-Independent Manner. | 2019 Mar 19 |
1 |
| 16 |
29320680 | K-Ras4B Remains Monomeric on Membranes over a Wide Range of Surface Densities and Lipid Compositions. | 2018 Jan 9 |
1 |
| 17 |
29429878 | Raf-1 Cysteine-Rich Domain Increases the Affinity of K-Ras/Raf at the Membrane, Promoting MAPK Signaling. | 2018 Mar 6 |
1 |
| 18 |
29610327 | Precise characterization of KRAS4b proteoforms in human colorectal cells and tumors reveals mutation/modification cross-talk. | 2018 Apr 17 |
1 |
| 19 |
30613331 | Discovery of Tetrahydropyridopyrimidines as Irreversible Covalent Inhibitors of KRAS-G12C with In Vivo Activity. | 2018 Dec 13 |
1 |
| 20 |
28457754 | Investigation of the structural requirements of K-Ras(G12D) selective inhibitory peptide KRpep-2d using alanine scans and cysteine bridging. | 2017 Jun 15 |
1 |
| 21 |
29033317 | Ras Binder Induces a Modified Switch-II Pocket in GTP and GDP States. | 2017 Dec 21 |
1 |
| 22 |
26423694 | Getting a Handle on RAS-targeted Therapies: Cysteine Directed Inhibitors. | 2016 |
1 |
| 23 |
26080442 | Ras-GTP dimers activate the Mitogen-Activated Protein Kinase (MAPK) pathway. | 2015 Jun 30 |
1 |
| 24 |
24138715 | Across the universe of K-RAS mutations in non-small-cell-lung cancer. | 2014 |
1 |
| 25 |
24852854 | KRAS mutations and M2PK upregulation in stool samples from individuals with positive fecal occult blood tests screened for colorectal cancer. | 2014 Mar-Apr |
1 |
| 26 |
17706379 | The NS3 proteins of global strains of bluetongue virus evolve into regional topotypes through negative (purifying) selection. | 2008 Jan 1 |
2 |
| 27 |
18680101 | Design of (Gd-DO3A)n-polydiamidopropanoyl-peptide nucleic acid-D(Cys-Ser-Lys-Cys) magnetic resonance contrast agents. | 2008 Dec |
2 |
| 28 |
18701486 | Sensitization to the lysosomal cell death pathway by oncogene-induced down-regulation of lysosome-associated membrane proteins 1 and 2. | 2008 Aug 15 |
1 |
| 29 |
17239391 | Characterisation of the role of zinc in the hepatitis C virus NS2/3 auto-cleavage and NS3 protease activities. | 2007 Mar 9 |
1 |
| 30 |
17611392 | Radiohybridization PET imaging of KRAS G12D mRNA expression in human pancreas cancer xenografts with [(64)Cu]DO3A-peptide nucleic acid-peptide nanoparticles. | 2007 Jun |
1 |
| 31 |
16139926 | Is there a prognostic role of K-ras point mutations in the serum of patients with advanced non-small cell lung cancer? | 2005 Dec |
1 |
| 32 |
14718395 | Rapid detection of K-ras mutations in bile by peptide nucleic acid-mediated PCR clamping and melting curve analysis: comparison with restriction fragment length polymorphism analysis. | 2004 Mar |
1 |
| 33 |
15115394 | Peptide-based inhibitors of the hepatitis C virus NS3 protease: structure-activity relationship at the C-terminal position. | 2004 May 6 |
1 |
| 34 |
20641287 | 64Cu-N,N'-Bis(S-benzoyl-thioglycoloyl)diaminopropanoate-KRAS-PNA-d(Cys-Ser-Lys-Cys) | 2004 |
6 |
| 35 |
20641936 | 99mTc-N,N'-Bis(S-benzoyl-thioglycoloyl)diamidopropanoyl-KRAS-PNA-d(Cys-Ser-Lys-Cys) | 2004 |
4 |
| 36 |
12706879 | Methylation patterns and K-ras mutations in tumor and paired serum of resected non-small-cell lung cancer patients. | 2003 Apr 25 |
1 |
| 37 |
11844705 | A designed P1 cysteine mimetic for covalent and non-covalent inhibitors of HCV NS3 protease. | 2002 Feb 25 |
1 |
| 38 |
10739955 | A new approach to gene mutation analysis using "GFP-Display". | 2000 Apr |
1 |
| 39 |
9514049 | K-ras point mutation occurs in the early stage of carcinogenesis in lung cancer. | 1998 Mar |
1 |
| 40 |
10726060 | The hepatitis C virus NS3 proteinase: structure and function of a zinc-containing serine proteinase. | 1998 |
4 |
| 41 |
9060645 | The NS3 proteinase domain of hepatitis C virus is a zinc-containing enzyme. | 1997 Apr |
3 |
| 42 |
9235976 | Mechanistic role of an NS4A peptide cofactor with the truncated NS3 protease of hepatitis C virus: elucidation of the NS4A stimulatory effect via kinetic analysis and inhibitor mapping. | 1997 Aug 5 |
1 |
| 43 |
8641983 | Detection of K-ras point mutations at codon 12 in pancreatic juice for the diagnosis of pancreatic cancer by hybridization protection assay: a simple method for the determination of the types of point mutation. | 1996 May |
1 |
| 44 |
9078466 | Establishment of an in vitro assay to characterize hepatitis C virus NS3-4A protease trans-processing activity. | 1996 |
1 |
| 45 |
7547927 | Binding of prenylated and polybasic peptides to membranes: affinities and intervesicle exchange. | 1995 Sep 19 |
1 |
| 46 |
16296004 | Post-translational processing of purified human K-ras in Xenopus oocytes. | 1991 |
1 |
| 47 |
2179417 | Ras oncogene mutations in basal cell carcinomas and squamous cell carcinomas of human skin. | 1990 Apr |
2 |
| 48 |
2183224 | Farnesol modification of Kirsten-ras exon 4B protein is essential for transformation. | 1990 Apr |
2 |
| 49 |
4060579 | Identification of nonstructural proteins encoded by viruses of the Bunyamwera serogroup (family Bunyaviridae). | 1985 May |
1 |
| 50 |
6308465 | Structure of the Ki-ras gene of the human lung carcinoma cell line Calu-1. | 1983 Aug 11-17 |
1 |