| 1 |
30762305 | Physiologically-Based Pharmacokinetic Models for CYP1A2 Drug-Drug Interaction Prediction: A Modeling Network of Fluvoxamine, Theophylline, Caffeine, Rifampicin, and Midazolam. | 2019 May |
1 |
| 2 |
31164617 | Study Protocol for a Pilot, Open-Label, Prospective, and Observational Study to Evaluate the Pharmacokinetics of Drugs Administered to Patients during Extracorporeal Circulation; Potential of In Vivo Cytochrome P450 Phenotyping to Optimise Pharmacotherapy. | 2019 May 13 |
1 |
| 3 |
29063606 | Harnessing Meta-analysis to Refine an Oncology Patient Population for Physiology-Based Pharmacokinetic Modeling of Drugs. | 2018 Feb |
1 |
| 4 |
27127017 | The CYTONOX trial. | 2016 May |
1 |
| 5 |
24695277 | Evaluation of human hepatocytes cultured by three-dimensional spheroid systems for drug metabolism. | 2014 |
1 |
| 6 |
25456436 | In vitro studies of berberine metabolism and its effect of enzyme induction on HepG2 cells. | 2014 Dec 2 |
3 |
| 7 |
29403890 | An in-vitro cocktail assay for assessing compound-mediated inhibition of six major cytochrome P450 enzymes. | 2014 Aug |
1 |
| 8 |
23153057 | Assessment of cytochrome P450 (1A2, 2B6, 2C9 and 3A4) induction in cryopreserved human hepatocytes cultured in 48-well plates using the cocktail strategy. | 2013 Apr |
1 |
| 9 |
23682612 | The effect of organic solvents on enzyme kinetic parameters of human CYP3A4 and CYP1A2 in vitro. | 2013 Oct |
1 |
| 10 |
21885687 | Cocktail approach for in vivo phenotyping of 5 major CYP450 isoenzymes: development of an effective sampling, extraction, and analytical procedure and pilot study with comparative genotyping. | 2012 Aug |
1 |
| 11 |
22483397 | High-sensitivity liquid chromatography-tandem mass spectrometry for the simultaneous determination of five drugs and their cytochrome P450-specific probe metabolites in human plasma. | 2012 May 1 |
1 |
| 12 |
22725721 | A pregnancy physiologically based pharmacokinetic (p-PBPK) model for disposition of drugs metabolized by CYP1A2, CYP2D6 and CYP3A4. | 2012 Nov |
1 |
| 13 |
20501911 | Metabolite formation kinetics and intrinsic clearance of phenacetin, tolbutamide, alprazolam, and midazolam in adenoviral cytochrome P450-transfected HepG2 cells and comparison with hepatocytes and in vivo. | 2010 Sep |
1 |
| 14 |
16857327 | Characterization of the cytochrome P450 enzymes involved in the metabolism of a new cardioprotective agent KR-33028. | 2006 Oct 10 |
1 |
| 15 |
16041547 | Cytochrome P450 mRNA expression in peripheral blood lymphocytes as a predictor of enzyme induction. | 2005 Sep |
1 |
| 16 |
16049126 | Automated assessment of time-dependent inhibition of human cytochrome P450 enzymes using liquid chromatography-tandem mass spectrometry analysis. | 2005 Nov |
1 |
| 17 |
11948533 | Evaluation of approach to predict the contribution of multiple cytochrome P450s in drug metabolism using relative activity factor: effects of the differences in expression levels of NADPH-cytochrome P450 reductase and cytochrome b(5) in the expression system and the differences in the marker activities. | 2002 Apr |
1 |
| 18 |
10562786 | Fentanyl inhibits metabolism of midazolam: competitive inhibition of CYP3A4 in vitro. | 1999 Jun |
1 |
| 19 |
9867310 | In vivo age-related changes in hepatic drug-oxidizing capacity in humans. | 1998 Aug |
1 |
| 20 |
8423765 | Identification and characterization of the cytochrome P450 enzymes involved in N-dealkylation of propafenone: molecular base for interaction potential and variable disposition of active metabolites. | 1993 Jan |
1 |