2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one

mitogen activated protein kinase 3 ; Rattus norvegicus







49 Article(s)
Download
PMID
Title
Pub. Year
#Total Relationships
1 35346134 The zinc transporter ZIP12 regulates monocrotaline-induced proliferation and migration of pulmonary arterial smooth muscle cells via the AKT/ERK signaling pathways. 2022 Mar 28 1
2 35574901 Low-intensity pulsed ultrasound promotes cell viability and inhibits apoptosis of H9C2 cardiomyocytes in 3D bioprinting scaffolds via PI3K-Akt and ERK1/2 pathways. 2022 May 15 1
3 33602886 NOX4/Src regulates ANP secretion through activating ERK1/2 and Akt/GATA4 signaling in beating rat hypoxic atria. 2021 Mar 1 2
4 33738663 Ginsenoside Compound K Promotes Proliferation, Migration and Differentiation of Schwann Cells via the Activation of MEK/ERK1/2 and PI3K/AKT Pathways. 2021 Jun 1
5 31086595 Pre-treatment with a combination of Shenmai and Danshen injection protects cardiomyocytes against hypoxia/reoxygenation- and H2O2-induced injury by inhibiting mitochondrial permeability transition pore opening. 2019 Jun 2
6 31369731 NMDA receptor-dependent signalling pathways regulate arginine vasopressin expression in the paraventricular nucleus of the rat. 2019 Nov 1 1
7 31602203 Adropin reduces hypoxia/reoxygenation-induced myocardial injury via the reperfusion injury salvage kinase pathway. 2019 Nov 1
8 30134819 Pharmacological postconditioning with Neuregulin-1 mimics the cardioprotective effects of ischaemic postconditioning via ErbB4-dependent activation of reperfusion injury salvage kinase pathway. 2018 Jul 31 1
9 28591364 Roles of the ERK1/2 and PI3K/PKB signaling pathways in regulating the expression of extracellular matrix genes in rat pulmonary artery smooth muscle cells. 2017 May 1
10 26840295 Ginsenoside-Rd Promotes Neurite Outgrowth of PC12 Cells through MAPK/ERK- and PI3K/AKT-Dependent Pathways. 2016 Jan 29 2
11 27606614 Periodic Mechanical Stress Activates PKCĪ“-Dependent EGFR Mitogenic Signals in Rat Chondrocytes via PI3K-Akt and ERK1/2. 2016 1
12 25338292 Repetitive ischemic preconditioning attenuates inflammatory reaction and brain damage after focal cerebral ischemia in rats: involvement of PI3K/Akt and ERK1/2 signaling pathway. 2015 Apr 2
13 25360842 Differential ERK1/2 Signaling and Hypertrophic Response to Endothelin-1 in Cardiomyocytes from SHR and Wistar-Kyoto Rats: A Potential Target for Combination Therapy of Hypertension. 2015 1
14 25533999 bFGF attenuates endoplasmic reticulum stress and mitochondrial injury on myocardial ischaemia/reperfusion via activation of PI3K/Akt/ERK1/2 pathway. 2015 Mar 1
15 26255195 Rutin, A Natural Flavonoid Protects PC12 Cells Against Sodium Nitroprusside-Induced Neurotoxicity Through Activating PI3K/Akt/mTOR and ERK1/2 Pathway. 2015 Sep 1
16 22674052 Fluoxetine upregulates phosphorylated-AKT and phosphorylated-ERK1/2 proteins in neural stem cells: evidence for a crosstalk between AKT and ERK1/2 pathways. 2013 Feb 1
17 23219579 Both PI3K/Akt and ERK1/2 pathways participate in the protection by dexmedetomidine against transient focal cerebral ischemia/reperfusion injury in rats. 2013 Feb 4 1
18 23254481 Platelet-derived growth factor-D induces expression of cyclooxygenase-2 in rat mesangial cells through activation of PI3K/PKB and PKCs. 2013 Feb 1
19 23460471 Snail mediates PDGF-BB-induced invasion of rat bone marrow mesenchymal stem cells in 3D collagen and chick chorioallantoic membrane. 2013 Sep 1
20 23889671 Simvastatin induces a central hypotensive effect via Ras-mediated signalling to cause eNOS up-regulation. 2013 Oct 1
21 22609091 bFGF inhibits ER stress induced by ischemic oxidative injury via activation of the PI3K/Akt and ERK1/2 pathways. 2012 Jul 20 1
22 20399244 A formulated red ginseng extract rescues PC12 cells from PCB-induced oxidative cell death through Nrf2-mediated upregulation of heme oxygenase-1 and glutamate cysteine ligase. 2010 Nov 28 1
23 20539939 PI3K/Akt signaling transduction pathway is involved in rat vascular smooth muscle cell proliferation induced by apelin-13. 2010 Jun 15 1
24 18983912 GSK3beta modulates PACAP-induced neuritogenesis in PC12 cells by acting downstream of Rap1 in a caveolae-dependent manner. 2009 Feb 2
25 19235132 Insulin regulation of proliferation involves activation of AKT and ERK 1/2 signaling pathways in vascular smooth muscle cells. 2009 May 1
26 19881297 Sevoflurane postconditioning protects chronically-infarcted rat hearts against ischemia-reperfusion injury by activation of pro-survival kinases and inhibition of mitochondrial permeability transition pore opening upon reperfusion. 2009 Nov 1
27 17497701 Lovastatin protects mesenchymal stem cells against hypoxia- and serum deprivation-induced apoptosis by activation of PI3K/Akt and ERK1/2. 2008 Jan 1 1
28 17674030 Cardioprotection induced by hydrogen sulfide preconditioning involves activation of ERK and PI3K/Akt pathways. 2008 Jan 1
29 17267947 Endothelial cell-pericyte cocultures induce PLA2 protein expression through activation of PKCalpha and the MAPK/ERK cascade. 2007 Apr 1
30 17694254 Apelin-13 and apelin-36 exhibit direct cardioprotective activity against ischemia-reperfusion injury. 2007 Nov 2
31 16508949 Sphingosine-1-phosphate induces COX-2 expression via PI3K/Akt and p42/p44 MAPK pathways in rat vascular smooth muscle cells. 2006 Jun 2
32 16634987 Insulin increases gelatinase activity in rat glomerular mesangial cells via ERK- and PI-3 kinase-dependent signalling. 2006 May 1
33 16798728 Rac1 mediates intestinal epithelial cell apoptosis via JNK. 2006 Dec 1
34 16847434 Leptin, the obesity-associated hormone, exhibits direct cardioprotective effects. 2006 Sep 1
35 16935846 Regulation of the RAP1/RAF-1/extracellularly regulated kinase-1/2 cascade and prolactin release by the phosphoinositide 3-kinase/AKT pathway in pituitary cells. 2006 Dec 1
36 15358610 Ischemic preconditioning protects by activating prosurvival kinases at reperfusion. 2005 Feb 1
37 15882976 Resveratrol upregulates heme oxygenase-1 expression via activation of NF-E2-related factor 2 in PC12 cells. 2005 Jun 17 1
38 15922325 Honokiol-induced neurite outgrowth promotion depends on activation of extracellular signal-regulated kinases (ERK1/2). 2005 Jun 1 1
39 15997243 Leptin induces rat glomerular mesangial cell hypertrophy, but does not regulate hyperplasia or apoptosis. 2005 Dec 1
40 16342423 PKC alpha-dependent regulation of the IGF1 receptor in adult and embryonic rat cardiomyocytes. 2005 Jul 1
41 15240011 Intracellular signalings underlying bradykinin-induced matrix metalloproteinase-9 expression in rat brain astrocyte-1. 2004 Oct 1
42 15541884 Rapid actions of estradiol on cyclic amp response-element binding protein phosphorylation in dorsal root ganglion neurons. 2004 1
43 12951049 Hepatocyte growth factor exerts a proliferative effect on oval cells through the PI3K/AKT signaling pathway. 2003 Sep 19 1
44 11801244 Apigenin and LY294002 prolong EGF-stimulated ERK1/2 activation in PC12 cells but are unable to induce full differentiation. 2002 Jan 16 2
45 11406465 Differential ANG II-induced growth activation pathways in mesenteric artery smooth muscle cells from SHR. 2001 Jul 1
46 11483646 Neuroprotection mediated by glial group-II metabotropic glutamate receptors requires the activation of the MAP kinase and the phosphatidylinositol-3-kinase pathways. 2001 Aug 1
47 10734171 Signal transduction cascade in staurosporine-induced prostaglandin E(2) production by rat peritoneal macrophages. 2000 Apr 1
48 10918442 Regulation of both apoptosis and cell survival by the v-Src oncoprotein. 2000 Aug 1
49 10516133 Differential regulation of MAP kinase by contraction and insulin in skeletal muscle: metabolic implications. 1999 Oct 1