| 1 |
34939274 | Squalene synthase predicts poor prognosis in stage I-III colon adenocarcinoma and synergizes squalene epoxidase to promote tumor progression. | 2022 Mar |
2 |
| 2 |
35045984 | Targeting Squalene Epoxidase Interrupts Homologous Recombination via the ER Stress Response and Promotes Radiotherapy Efficacy. | 2022 Apr 1 |
2 |
| 3 |
35101444 | Mitochondrial respiratory chain dysfunction alters ER sterol sensing and mevalonate pathway activity. | 2022 Mar |
1 |
| 4 |
35359411 | Transcriptomics Reveals the Mevalonate and Cholesterol Pathways Blocking as Part of the Bacterial Cyclodipeptides Cytotoxic Effects in HeLa Cells of Human Cervix Adenocarcinoma. | 2022 |
1 |
| 5 |
35398802 | Structural enzymology of cholesterol biosynthesis and storage. | 2022 Jun |
2 |
| 6 |
35552960 | SQLE inhibition suppresses the development of pancreatic ductal adenocarcinoma and enhances its sensitivity to chemotherapeutic agents in vitro. | 2022 May 12 |
2 |
| 7 |
32979157 | The Degron Architecture of Squalene Monooxygenase and How Specific Lipids Calibrate Levels of This Key Cholesterol Synthesis Enzyme. | 2021 |
5 |
| 8 |
33511005 | A Novel Long Non-Coding RNA lnc030 Maintains Breast Cancer Stem Cell Stemness by Stabilizing SQLE mRNA and Increasing Cholesterol Synthesis. | 2021 Jan |
2 |
| 9 |
33647280 | Squalene Epoxidase Induces Nonalcoholic Steatohepatitis Via Binding to Carbonic Anhydrase III and is a Therapeutic Target. | 2021 Jun |
1 |
| 10 |
33663541 | Weighted gene co-expression network analysis to identify key modules and hub genes related to hyperlipidaemia. | 2021 Mar 4 |
1 |
| 11 |
33664822 | Squalene epoxidase expression is associated with breast tumor progression and with a poor prognosis in breast cancer. | 2021 Apr |
2 |
| 12 |
33791309 | MYC Enhances Cholesterol Biosynthesis and Supports Cell Proliferation Through SQLE. | 2021 |
4 |
| 13 |
33933449 | The mammalian cholesterol synthesis enzyme squalene monooxygenase is proteasomally truncated to a constitutively active form. | 2021 Jan-Jun |
7 |
| 14 |
34268906 | Squalene epoxidase promotes colorectal cancer cell proliferation through accumulating calcitriol and activating CYP24A1-mediated MAPK signaling. | 2021 Aug |
3 |
| 15 |
34335030 | SQLE Mediates Metabolic Reprogramming to Promote LN Metastasis in Castration-Resistant Prostate Cancer. | 2021 |
2 |
| 16 |
34417456 | MiR-205-driven downregulation of cholesterol biosynthesis through SQLE-inhibition identifies therapeutic vulnerability in aggressive prostate cancer. | 2021 Aug 20 |
4 |
| 17 |
34440098 | Enzymes in the Cholesterol Synthesis Pathway: Interactomics in the Cancer Context. | 2021 Jul 26 |
1 |
| 18 |
34444698 | Orphan Nuclear Receptor RORγ Modulates the Genome-Wide Binding of the Cholesterol Metabolic Genes during Mycotoxin-Induced Liver Injury. | 2021 Jul 25 |
1 |
| 19 |
34518524 | LPCAT1 reprogramming cholesterol metabolism promotes the progression of esophageal squamous cell carcinoma. | 2021 Sep 13 |
1 |
| 20 |
34726809 | Osteoblasts impair cholesterol synthesis in chondrocytes via Notch1 signalling. | 2021 Dec |
1 |
| 21 |
32170014 | A key mammalian cholesterol synthesis enzyme, squalene monooxygenase, is allosterically stabilized by its substrate. | 2020 Mar 31 |
7 |
| 22 |
32314495 | Squalene epoxidase-induced cholesteryl ester accumulation promotes nasopharyngeal carcinoma development by activating PI3K/AKT signaling. | 2020 Jul |
2 |
| 23 |
32360125 | Squalene monooxygenase: a journey to the heart of cholesterol synthesis. | 2020 Jul |
3 |
| 24 |
32698040 | Cholesterol metabolism: New functions and therapeutic approaches in cancer. | 2020 Aug |
1 |
| 25 |
32755570 | The MARCH6-SQLE Axis Controls Endothelial Cholesterol Homeostasis and Angiogenic Sprouting. | 2020 Aug 4 |
5 |
| 26 |
30626872 | Structure and inhibition mechanism of the catalytic domain of human squalene epoxidase. | 2019 Jan 9 |
3 |
| 27 |
30626880 | A chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to SQLE inhibition. | 2019 Jan 9 |
3 |
| 28 |
30658189 | Differential use of E2 ubiquitin conjugating enzymes for regulated degradation of the rate-limiting enzymes HMGCR and SQLE in cholesterol biosynthesis. | 2019 Feb |
6 |
| 29 |
30734525 | Squalene epoxidase promotes the proliferation and metastasis of lung squamous cell carcinoma cells though extracellular signal-regulated kinase signaling. | 2019 Mar |
2 |
| 30 |
30760928 | Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death. | 2019 Mar |
2 |
| 31 |
30792392 | The shape of human squalene epoxidase expands the arsenal against cancer. | 2019 Feb 21 |
2 |
| 32 |
30940729 | Non-canonical ubiquitination of the cholesterol-regulated degron of squalene monooxygenase. | 2019 May 17 |
8 |
| 33 |
31072053 | Squalene Epoxidase Correlates E-Cadherin Expression and Overall Survival in Colorectal Cancer Patients: The Impact on Prognosis and Correlation to Clinicopathologic Features | 2019 May 8 |
1 |
| 34 |
31356817 | OSBPL2 deficiency upregulate SQLE expression increasing intracellular cholesterol and cholesteryl ester by AMPK/SP1 and SREBF2 signalling pathway. | 2019 Oct 15 |
2 |
| 35 |
31471528 | Valosin-containing protein mediates the ERAD of squalene monooxygenase and its cholesterol-responsive degron. | 2019 Sep 20 |
1 |
| 36 |
29510567 | Phenolic Compounds from Belamcanda chinensis Seeds. | 2018 Mar 5 |
2 |
| 37 |
29596888 | Squalene epoxidase as a promising metabolic target in cancer treatment. | 2018 Jul 1 |
2 |
| 38 |
29765154 | The cancer-associated microprotein CASIMO1 controls cell proliferation and interacts with squalene epoxidase modulating lipid droplet formation. | 2018 Aug |
2 |
| 39 |
30367044 | Dietary cholesterol promotes steatohepatitis related hepatocellular carcinoma through dysregulated metabolism and calcium signaling. | 2018 Oct 26 |
1 |
| 40 |
27989886 | Intracoronary Imaging, Cholesterol Efflux, and Transcriptomes After Intensive Statin Treatment: The YELLOW II Study. | 2017 Feb 14 |
1 |
| 41 |
28069586 | SQLE induces epithelial-to-mesenchymal transition by regulating of miR-133b in esophageal squamous cell carcinoma. | 2017 Feb 6 |
2 |
| 42 |
28342963 | New insights into cellular cholesterol acquisition: promoter analysis of human HMGCR and SQLE, two key control enzymes in cholesterol synthesis. | 2017 Jul |
4 |
| 43 |
28357032 | Meta-analysis reveals up-regulation of cholesterol processes in non-alcoholic and down-regulation in alcoholic fatty liver disease. | 2017 Mar 18 |
2 |
| 44 |
28595267 | Cholesterol uptake and regulation in high-grade and lethal prostate cancers. | 2017 Aug 1 |
2 |
| 45 |
28686302 | Plasmalogen homeostasis - regulation of plasmalogen biosynthesis and its physiological consequence in mammals. | 2017 Sep |
3 |
| 46 |
28972164 | A conserved degron containing an amphipathic helix regulates the cholesterol-mediated turnover of human squalene monooxygenase, a rate-limiting enzyme in cholesterol synthesis. | 2017 Dec 8 |
10 |
| 47 |
29222193 | A cholesterol-sensing mechanism unfolds. | 2017 Dec 8 |
6 |
| 48 |
26527619 | A MARCH6 and IDOL E3 Ubiquitin Ligase Circuit Uncouples Cholesterol Synthesis from Lipoprotein Uptake in Hepatocytes. | 2016 Jan 15 |
2 |
| 49 |
26777065 | Squalene epoxidase is a bona fide oncogene by amplification with clinical relevance in breast cancer. | 2016 Jan 18 |
1 |
| 50 |
27246191 | Cholesterol biosynthesis pathway as a novel mechanism of resistance to estrogen deprivation in estrogen receptor-positive breast cancer. | 2016 Jun 1 |
1 |