Gangliosides

amyloid beta precursor protein ; Homo sapiens







49 Article(s)
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1 35580354 Amyloid β Dodecamer Disrupts the Neuronal Membrane More Strongly than the Mature Fibril: Understanding the Role of Oligomers in Neurotoxicity. 2022 May 26 2
2 34110944 The emerging role of the sigma-1 receptor in autophagy: hand-in-hand targets for the treatment of Alzheimer's. 2021 May 1
3 34768981 Gene Therapy Strategy for Alzheimer's and Parkinson's Diseases Aimed at Preventing the Formation of Neurotoxic Oligomers in SH-SY5Y Cells. 2021 Oct 26 2
4 32142821 Aβ-ganglioside interactions in the pathogenesis of Alzheimer's disease. 2020 Aug 1 3
5 32567070 Progress toward Alzheimer's disease treatment: Leveraging the Achilles' heel of Aβ oligomers? 2020 Aug 1
6 32916822 The Role of Lipid Environment in Ganglioside GM1-Induced Amyloid β Aggregation. 2020 Sep 9 1
7 31474736 Computational Study on the Assembly of Amyloid β-Peptides in the Hydrophobic Environment. 2019 2
8 29747822 Ganglioside-Mediated Assembly of Amyloid β-Protein: Roles in Alzheimer's Disease. 2018 6
9 30018137 Amyloid-β fibrils assembled on ganglioside-enriched membranes contain both parallel β-sheets and turns. 2018 Sep 7 5
10 30257562 Preferential Intercalation of Human Amyloid-β Peptide into Interbilayer Region of Lipid-Raft Membrane in Macromolecular Crowding Environment. 2018 Oct 18 1
11 30457145 The Alzheimer's disease amyloid-β peptide affects the size-dynamics of raft-mimicking Lo domains in GM1-containing lipid bilayers. 2018 Dec 5 1
12 27352802 Common molecular mechanism of amyloid pore formation by Alzheimer's β-amyloid peptide and α-synuclein. 2016 Jun 29 1
13 27373967 Anti-amyloidogenic effects of glycosphingolipid synthesis inhibitors occur independently of ganglioside alterations. 2016 Sep 1
14 27933798 High-Affinity Binding of Monomeric but Not Oligomeric Amyloid-β to Ganglioside GM1 Containing Nanodiscs. 2016 Dec 6 1
15 25406316 Small liposomes accelerate the fibrillation of amyloid β (1-40). 2015 Jan 9 1
16 26149926 Lipids in Amyloid-β Processing, Aggregation, and Toxicity. 2015 1
17 24995708 A distinct subfraction of Aβ is responsible for the high-affinity Pittsburgh compound B-binding site in Alzheimer's disease brain. 2014 Nov 1
18 25140899 Deciphering the glycolipid code of Alzheimer's and Parkinson's amyloid proteins allowed the creation of a universal ganglioside-binding peptide. 2014 2
19 25399921 Comparison between the aggregation of human and rodent amyloid β-proteins in GM1 ganglioside clusters. 2014 Dec 9 5
20 23688073 Binding and aggregation mechanism of amyloid β-peptides onto the GM1 ganglioside-containing lipid membrane. 2013 Jul 11 1
21 22470521 Amyloid precursor protein (APP) mediated regulation of ganglioside homeostasis linking Alzheimer's disease pathology with ganglioside metabolism. 2012 3
22 22947931 Two-step mechanism of membrane disruption by Aβ through membrane fragmentation and pore formation. 2012 Aug 22 1
23 20831659 Ganglioside-mediated aggregation of amyloid β-proteins (Aβ): comparison between Aβ-(1-42) and Aβ-(1-40). 2011 Mar 4
24 21214549 Pathological significance of ganglioside clusters in Alzheimer's disease. 2011 Mar 4
25 21318142 Formation of Toxic Amyloid Fibrils by Amyloid β-Protein on Ganglioside Clusters. 2011 Jan 13 1
26 21682276 Mechanism of amyloid β-protein aggregation mediated by GM1 ganglioside clusters. 2011 Jul 26 1
27 20074569 NMR characterization of the interactions between lyso-GM1 aqueous micelles and amyloid beta. 2010 Feb 19 5
28 20117237 Abeta polymerization through interaction with membrane gangliosides. 2010 Aug 8
29 20226163 Surface-induced phase separation of a sphingomyelin/cholesterol/ganglioside GM1-planar bilayer on mica surfaces and microdomain molecular conformation that accelerates Abeta oligomerization. 2010 Jun 3
30 20423299 Lipid membranes and beta-amyloid: a harmful connection. 2010 Aug 1
31 20930481 [Visualization of amyloid formation processes on cell membranes: gangliosides as key molecules for the onset of amyloidosis]. 2010 Oct 1
32 19052862 Up-and-down topological mode of amyloid beta-peptide lying on hydrophilic/hydrophobic interface of ganglioside clusters. 2009 Nov 3
33 19138679 The interaction of amyloid Abeta(1-40) with lipid bilayers and ganglioside as studied by 31P solid-state NMR. 2009 Mar 1
34 19217912 Exploring the mechanism of beta-amyloid toxicity attenuation by multivalent sialic acid polymers through the use of mathematical models. 2009 May 21 1
35 18508118 Development of photocrosslinked sialic acid containing polymers for use in Abeta toxicity attenuation. 2008 Aug-Sep 1
36 18975139 Disordered proteins: biological membranes as two-dimensional aggregation matrices. 2008 1
37 17135262 A ganglioside-induced toxic soluble Abeta assembly. Its enhanced formation from Abeta bearing the Arctic mutation. 2007 Jan 26 1
38 17321494 Role of gangliosides in Alzheimer's disease. 2007 Aug 2
39 17382287 Physicochemical interactions of amyloid beta-peptide with lipid bilayers. 2007 Aug 1
40 17887730 Clustered negative charges on the lipid membrane surface induce beta-sheet formation of prion protein fragment 106-126. 2007 Oct 16 1
41 16721824 Amyloid beta oligomerization is induced by brain lipid rafts. 2006 Oct 15 2
42 15709486 Membrane disordering effects of beta-amyloid peptides. 2005 1
43 15002743 Alzheimer's disease: NMR studies of asialo (GM1) and trisialo (GT1b) ganglioside interactions with Abeta(1-40) peptide in a membrane mimic environment. 2004 Feb 4
44 12659848 Formation of a membrane-active form of amyloid beta-protein in raft-like model membranes. 2003 Apr 4 2
45 12044171 Interactions of amyloid beta-protein with various gangliosides in raft-like membranes: importance of GM1 ganglioside-bound form as an endogenous seed for Alzheimer amyloid. 2002 Jun 11 11
46 11859933 Gangliosides inhibit the release of interleukin-1beta in amyloid beta-protein-treated human monocytic cells. 2001 Dec 2
47 9972868 GM1 inhibits amyloid beta-protein-induced cytokine release. 1999 Feb 2
48 10194329 Interactions of amyloid beta-peptide (1-40) with ganglioside-containing membranes. 1999 Mar 30 4
49 9037173 The interaction between Alzheimer amyloid beta(1-40) peptide and ganglioside GM1-containing membranes. 1997 Feb 3 1