| 1 |
34982265 | OSI-906 restores the sensitivity of ovarian clear cell carcinoma to cisplatin by targeting the IGF1R/AKT pathway. | 2022 Jan 4 |
2 |
| 2 |
35154476 | Overexpression of BACH1 mediated by IGF2 facilitates hepatocellular carcinoma growth and metastasis via IGF1R and PTK2. | 2022 |
1 |
| 3 |
35197754 | Linsitinib and aspirin as the IGF1-R antagonists, inhibit regorafenib-resistant chemotherapy in colon cancer. | 2022 Feb |
3 |
| 4 |
35574033 | Type 1 Insulin-Like Growth Factor Receptor Nuclear Localization in High-Grade Glioma Cells Enhances Motility, Metabolism, and In Vivo Tumorigenesis. | 2022 |
1 |
| 5 |
33023892 | The RNA m6A Reader YTHDF2 Maintains Oncogene Expression and Is a Targetable Dependency in Glioblastoma Stem Cells. | 2021 Feb |
1 |
| 6 |
33075426 | The cytoskeleton actin binding protein filamin A impairs both IGF2 mitogenic effects and the efficacy of IGF1R inhibitors in adrenocortical cancer cells. | 2021 Jan 28 |
1 |
| 7 |
34071893 | Combination Treatment of OSI-906 with Aurora B Inhibitor Reduces Cell Viability via Cyclin B1 Degradation-Induced Mitotic Slippage. | 2021 May 27 |
1 |
| 8 |
34075028 | IGF1-mediated HOXA13 overexpression promotes colorectal cancer metastasis through upregulating ACLY and IGF1R. | 2021 Jun 1 |
1 |
| 9 |
34106558 | Systematic screening reveals synergistic interactions that overcome MAPK inhibitor resistance in cancer cells. | 2021 Jun 9 |
1 |
| 10 |
34110249 | Autophagy induction by IGF1R inhibition with picropodophyllin and linsitinib. | 2021 Aug |
1 |
| 11 |
34964902 | Dual IGF1R/IR inhibitors in combination with GD2-CAR T-cells display a potent anti-tumor activity in diffuse midline glioma H3K27M-mutant. | 2021 Dec 29 |
1 |
| 12 |
31490549 | IGF-1R pathway activation as putative biomarker for linsitinib therapy to revert tamoxifen resistance in ER-positive breast cancer. | 2020 Apr 15 |
3 |
| 13 |
31792037 | Linsitinib (OSI-906) for the Treatment of Adult and Pediatric Wild-Type Gastrointestinal Stromal Tumors, a SARC Phase II Study. | 2020 Apr 15 |
1 |
| 14 |
32398667 | Insulin-like growth factor 1-induced enolase 2 deacetylation by HDAC3 promotes metastasis of pancreatic cancer. | 2020 May 13 |
1 |
| 15 |
32427884 | Critical role of SOX2-IGF2 signaling in aggressiveness of bladder cancer. | 2020 May 19 |
1 |
| 16 |
30701095 | Targeting the insulin-like growth factor-1 receptor in MTAP-deficient renal cell carcinoma. | 2019 |
2 |
| 17 |
30838516 | IGF and mTOR pathway expression and in vitro effects of linsitinib and mTOR inhibitors in adrenocortical cancer. | 2019 Jun |
1 |
| 18 |
31042587 | IGF1R/IRS1 targeting has cytotoxic activity and inhibits PI3K/AKT/mTOR and MAPK signaling in acute lymphoblastic leukemia cells. | 2019 Aug 1 |
1 |
| 19 |
31467485 | IGF-1R Inhibition Suppresses Cell Proliferation and Increases Radiosensitivity in Nasopharyngeal Carcinoma Cells. | 2019 |
3 |
| 20 |
31480400 | Ceritinib-Induced Regression of an Insulin-Like Growth Factor-Driven Neuroepithelial Brain Tumor. | 2019 Aug 30 |
1 |
| 21 |
31676869 | Establishment of a novel human CIC-DUX4 sarcoma cell line, Kitra-SRS, with autocrine IGF-1R activation and metastatic potential to the lungs. | 2019 Nov 1 |
2 |
| 22 |
29251331 | Upregulation of IGF1 by tumor-associated macrophages promotes the proliferation and migration of epithelial ovarian cancer cells. | 2018 Feb |
3 |
| 23 |
29476383 | A phase 2 study of OSI-906 (linsitinib, an insulin-like growth factor receptor-1 inhibitor) in patients with asymptomatic or mildly symptomatic (non-opioid requiring) metastatic castrate resistant prostate cancer (CRPC). | 2018 Jun |
1 |
| 24 |
29731738 | Insulin-Like Growth Factor 2 mRNA-Binding Protein 3 Influences Sensitivity to Anti-IGF System Agents Through the Translational Regulation of IGF1R. | 2018 |
1 |
| 25 |
30139840 | A Phase I Dose-Escalation Study of Linsitinib (OSI-906), a Small-Molecule Dual Insulin-Like Growth Factor-1 Receptor/Insulin Receptor Kinase Inhibitor, in Combination with Irinotecan in Patients with Advanced Cancer. | 2018 Dec |
4 |
| 26 |
27686971 | Phase 2 Study of Erlotinib in Combination With Linsitinib (OSI-906) or Placebo in Chemotherapy-Naive Patients With Non-Small-Cell Lung Cancer and Activating Epidermal Growth Factor Receptor Mutations. | 2017 Jan |
1 |
| 27 |
28440057 | Overcoming Linsitinib intrinsic resistance through inhibition of nuclear factor-κB signaling in esophageal squamous cell carcinoma. | 2017 Jun |
2 |
| 28 |
28544544 | Insulin-like growth factor-1 signaling is responsible for cathepsin G-induced aggregation of breast cancer MCF-7 cells. | 2017 Aug |
1 |
| 29 |
28751539 | Mechanisms of Resistance to NTRK Inhibitors and Therapeutic Strategies in NTRK1-Rearranged Cancers. | 2017 Oct |
1 |
| 30 |
26561558 | InsR/IGF1R Pathway Mediates Resistance to EGFR Inhibitors in Glioblastoma. | 2016 Apr 1 |
1 |
| 31 |
26831715 | Phase I Dose-Escalation Study of Linsitinib (OSI-906) and Erlotinib in Patients with Advanced Solid Tumors. | 2016 Jun 15 |
1 |
| 32 |
26956669 | CRM1 Inhibition Promotes Cytotoxicity in Ewing Sarcoma Cells by Repressing EWS-FLI1-Dependent IGF-1 Signaling. | 2016 May 1 |
2 |
| 33 |
27196766 | Sensitizing Triple-Negative Breast Cancer to PI3K Inhibition by Cotargeting IGF1R. | 2016 Jul |
2 |
| 34 |
27299695 | The TGFβ pathway stimulates ovarian cancer cell proliferation by increasing IGF1R levels. | 2016 Oct 15 |
1 |
| 35 |
27638195 | Thyrotropin and Insulin-Like Growth Factor 1 Receptor Crosstalk Upregulates Sodium-Iodide Symporter Expression in Primary Cultures of Human Thyrocytes. | 2016 Dec |
3 |
| 36 |
27694157 | A Randomized Phase II Study of Linsitinib (OSI-906) Versus Topotecan in Patients With Relapsed Small-Cell Lung Cancer. | 2016 Oct |
1 |
| 37 |
25208878 | Phase I study of intermittent oral dosing of the insulin-like growth factor-1 and insulin receptors inhibitor OSI-906 in patients with advanced solid tumors. | 2015 Feb 15 |
1 |
| 38 |
25212606 | A phase I study of continuous oral dosing of OSI-906, a dual inhibitor of insulin-like growth factor-1 and insulin receptors, in patients with advanced solid tumors. | 2015 Feb 15 |
2 |
| 39 |
25303978 | A tale of two receptors: insulin and insulin-like growth factor signaling in cancer. | 2015 Feb 15 |
1 |
| 40 |
25335932 | A phase Ib study of linsitinib (OSI-906), a dual inhibitor of IGF-1R and IR tyrosine kinase, in combination with everolimus as treatment for patients with refractory metastatic colorectal cancer. | 2015 Feb |
2 |
| 41 |
25483727 | Basal expression of insulin-like growth factor 1 receptor determines intrinsic resistance of cancer cells to a phosphatidylinositol 3-kinase inhibitor ZSTK474. | 2015 Feb |
1 |
| 42 |
25609059 | Trabectedin efficacy in Ewing sarcoma is greatly increased by combination with anti-IGF signaling agents. | 2015 Mar 15 |
2 |
| 43 |
25795408 | Linsitinib (OSI-906) versus placebo for patients with locally advanced or metastatic adrenocortical carcinoma: a double-blind, randomised, phase 3 study. | 2015 Apr |
1 |
| 44 |
26041671 | Targeting the insulin-like growth factor receptor and Src signaling network for the treatment of non-small cell lung cancer. | 2015 Jun 4 |
3 |
| 45 |
24173770 | In vivo analysis of insulin-like growth factor type 1 receptor humanized monoclonal antibody MK-0646 and small molecule kinase inhibitor OSI-906 in colorectal cancer. | 2014 Jan |
2 |
| 46 |
24667688 | OVA66 increases cell growth, invasion and survival via regulation of IGF-1R-MAPK signaling in human cancer cells. | 2014 Jul |
2 |
| 47 |
24759003 | Mechanism of repression of 11β-hydroxysteroid dehydrogenase type 1 by growth hormone in 3T3-L1 adipocytes. | 2014 |
1 |
| 48 |
23515613 | ERK phosphorylation is predictive of resistance to IGF-1R inhibition in small cell lung cancer. | 2013 Jun |
1 |
| 49 |
23531874 | A kinase-independent biological activity for insulin growth factor-1 receptor (IGF-1R) : implications for inhibition of the IGF-1R signal. | 2013 Mar |
1 |
| 50 |
23688189 | IR/IGF1R signaling as potential target for treatment of high-grade osteosarcoma. | 2013 May 20 |
2 |