Curcumin

Jun proto-oncogene, AP-1 transcription factor subunit ; Homo sapiens







61 Article(s)
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1 35361044 Curcumin analog, GO-Y078, induces HO-1 transactivation-mediated apoptotic cell death of oral cancer cells by triggering MAPK pathways and AP-1 DNA-binding activity. 2022 Apr 1
2 34229599 Hypoxia-induced preadipocyte factor 1 expression in human lung fibroblasts through ERK/PEA3/c-Jun pathway. 2021 Jul 6 1
3 34355287 Synthetic curcumin analog: inhibiting the invasion, angiogenesis, and metastasis in human laryngeal carcinoma cells via NF-kB pathway. 2021 Aug 1
4 31630418 IL-17 stimulates the expression of CCL2 in cardiac myocytes via Act1/TRAF6/p38MAPK-dependent AP-1 activation. 2020 Jan 1
5 30395942 Co-activation of WT1 and AP-1 proteins on WT1 gene promoter to induce WT1 gene expression in K562 cells. 2019 Jan 3
6 32083122 Curcumin Inhibits ERK/c-Jun Expressions and Phosphorylation against Endometrial Carcinoma. 2019 3
7 29401702 Bioactive Dietary VDR Ligands Regulate Genes Encoding Biomarkers of Skin Repair That Are Associated with Risk for Psoriasis. 2018 Feb 4 1
8 26651837 Neuroprotective effects of curcumin on endothelin-1 mediated cell death in hippocampal neurons. 2017 Jun 3
9 28684765 Cervical cancer stem cells manifest radioresistance: Association with upregulated AP-1 activity. 2017 Jul 6 2
10 27424491 Role of TGF-β-induced Claudin-4 expression through c-Jun signaling in non-small cell lung cancer. 2016 Oct 1
11 27580989 Curcumin Suppresses Proliferation and Migration and Induces Apoptosis on Human Placental Choriocarcinoma Cells via ERK1/2 and SAPK/JNK MAPK Signaling Pathways. 2016 Oct 1 1
12 26496980 Co-treatment of THP-1 cells with naringenin and curcumin induces cell cycle arrest and apoptosis via numerous pathways. 2015 Dec 1
13 23467542 Both NF-κB and c-Jun/AP-1 involved in anti-β2GPI/β2GPI-induced tissue factor expression in monocytes. 2013 Apr 1
14 23616010 TF/FVIIa/PAR2 promotes cell proliferation and migration via PKCα and ERK-dependent c-Jun/AP-1 pathway in colon cancer cell line SW620. 2013 Oct 2
15 23875250 Curcumin induces cell cycle arrest and apoptosis of prostate cancer cells by regulating the expression of IkappaBalpha, c-Jun and androgen receptor. 2013 Jun 2
16 22298641 Curcumin inhibits protein phosphatases 2A and 5, leading to activation of mitogen-activated protein kinases and death in tumor cells. 2012 Apr 1
17 22443687 Curcumin induces the apoptosis of human monocytic leukemia THP-1 cells via the activation of JNK/ERK pathways. 2012 Mar 24 2
18 21044622 Role of JNK and c-Jun signaling pathway in regulation of human serum paraoxonase 1 gene transcription by berberine in human HepG2 cells. 2011 Jan 15 1
19 21314641 Roles of the ERK, JNK/AP-1/cyclin D1-CDK4 pathway in silica-induced cell cycle changes in human embryo lung fibroblast cells. 2011 Jul 2
20 20302927 Oxidative stress modulates PPAR gamma in vascular endothelial cells. 2010 Jun 15 1
21 20615395 Glial cell line-derived neurotrophic factor induces cell migration and matrix metalloproteinase-13 expression in glioma cells. 2010 Oct 15 1
22 21364631 Role of the JNK/c-Jun/AP-1 signaling pathway in galectin-1-induced T-cell death. 2010 1
23 19393026 Ischemia activates JNK/c-Jun/AP-1 pathway to up-regulate 14-3-3gamma in astrocyte. 2009 May 1
24 20141610 TNF-alpha induces TGF-beta1 expression in lung fibroblasts at the transcriptional level via AP-1 activation. 2009 Aug 2
25 18628248 Quercetin inhibition of tumor invasion via suppressing PKC delta/ERK/AP-1-dependent matrix metalloproteinase-9 activation in breast carcinoma cells. 2008 Sep 1
26 18646516 [Overexpression and higher phosphorylation of p53 induced by benzo(a) pyrene through activated protein 1 independent pathway]. 2008 May 1
27 16978906 Role of activator protein-1 on the effect of arginine-glycine-aspartic acid containing peptides on transforming growth factor-beta1 promoter activity. 2007 2
28 17569214 Molecular targets of curcumin. 2007 1
29 16125882 Overexpression of cyclin D1-CDK4 in silica-induced transformed cells is due to activation of ERKs, JNKs/AP-1 pathway. 2006 Jan 25 1
30 15514944 Constitutive activation of transcription factor AP-1 in cervical cancer and suppression of human papillomavirus (HPV) transcription and AP-1 activity in HeLa cells by curcumin. 2005 Mar 1 6
31 16053715 Curcumin derivatives inhibit the formation of Jun-Fos-DNA complex independently of their conserved cysteine residues. 2005 Jul 31 2
32 16083495 Novel curcumin- and emodin-related compounds identified by in silico 2D/3D conformer screening induce apoptosis in tumor cells. 2005 Aug 5 2
33 16358608 C-C chemokine ligand 2 gene expression in nasal polyp fibroblasts: possible implication in the pathogenesis of nasal polyposis. 2005 Nov 1
34 14755151 Role of fibroblast growth factor-2 in the expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human intestinal myofibroblasts. 2004 2
35 15139522 Modulation of AP-1 by natural chemopreventive compounds in human colon HT-29 cancer cell line. 2004 Apr 1
36 15256484 Curcumin induces c-jun N-terminal kinase-dependent apoptosis in HCT116 human colon cancer cells. 2004 Nov 2
37 15356994 Suppression of protein kinase C and nuclear oncogene expression as possible action mechanisms of cancer chemoprevention by Curcumin. 2004 Jul 1
38 15358181 Synthetic curcumin analogs inhibit activator protein-1 transcription and tumor-induced angiogenesis. 2004 Aug 20 1
39 12514113 Curcumin alters EpRE and AP-1 binding complexes and elevates glutamate-cysteine ligase gene expression. 2003 Mar 1
40 12628923 Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome. 2003 Mar 17 2
41 12631113 Tumor necrosis factor-alpha stimulates fractalkine production by mesangial cells and regulates monocyte transmigration: down-regulation by cAMP. 2003 Feb 1
42 12806293 Arrest of apoptosis in auditory neurons: implications for sensorineural preservation in cochlear implantation. 2003 May 1
43 12825130 Matrix metalloproteinase-3 secretion from human colonic subepithelial myofibroblasts: role of interleukin-17. 2003 2
44 12853969 Transforming growth factor-beta1 activates interleukin-6 expression in prostate cancer cells through the synergistic collaboration of the Smad2, p38-NF-kappaB, JNK, and Ras signaling pathways. 2003 Jul 10 1
45 14627502 Inhibitory effect of curcumin on proliferation of K562 cells involves down-regulation of p210(bcr/abl) initiated Ras signal transduction pathway. 2003 Nov 2
46 12128007 Estradiol protects dopaminergic neurons in a MPP+Parkinson's disease model. 2002 Jun 3
47 11678207 Role of AP-1 and HIF-1 transcription factors in TGF-beta activation of VEGF expression. 2001 1
48 11731421 The constitutive photomorphogenesis 9 signalosome directs vascular endothelial growth factor production in tumor cells. 2001 Dec 1 1
49 10918449 Molecular mechanisms implicated in galectin-1-induced apoptosis: activation of the AP-1 transcription factor and downregulation of Bcl-2. 2000 Aug 2
50 10972672 Anti-apoptotic effect of quercetin: intervention in the JNK- and ERK-mediated apoptotic pathways. 2000 Sep 2