| 1 |
29753091 | Increase in constitutively active MEK1 species by introduction of MEK1 mutations identified in cancers. | 2019 Jan |
4 |
| 2 |
26787465 | Direct interaction of Ste11 and Mkk1/2 through Nst1 integrates high-osmolarity glycerol and pheromone pathways to the cell wall integrity MAPK pathway. | 2016 Jan |
1 |
| 3 |
26993765 | BAY 11-7085 induces glucocorticoid receptor activation and autophagy that collaborate with apoptosis to induce human synovial fibroblast cell death. | 2016 Apr 26 |
1 |
| 4 |
27169363 | A Phos-tag SDS-PAGE method that effectively uses phosphoproteomic data for profiling the phosphorylation dynamics of MEK1. | 2016 Jul |
1 |
| 5 |
27793200 | Subcellular localisation of pMEK has a different prognosis in locally advanced head and neck cancer treated with concomitant radiochemotherapy. | 2016 Oct 28 |
2 |
| 6 |
26350500 | A flexible codon in genomically recoded Escherichia coli permits programmable protein phosphorylation. | 2015 Sep 9 |
1 |
| 7 |
23549785 | ERK2 but not ERK1 mediates HGF-induced motility in non-small cell lung carcinoma cell lines. | 2013 Jun 1 |
2 |
| 8 |
23562553 | Antitumor activity of methyl gallate by inhibition of focal adhesion formation and Akt phosphorylation in glioma cells. | 2013 Aug |
1 |
| 9 |
23653349 | p21-activated kinase 1 (PAK1) can promote ERK activation in a kinase-independent manner. | 2013 Jul 5 |
2 |
| 10 |
23889968 | An MAPK-dependent pathway induces epithelial-mesenchymal transition via Twist activation in human breast cancer cell lines. | 2013 Aug |
1 |
| 11 |
21525007 | Ras/mitogen-activated protein kinase (MAPK) signaling modulates protein stability and cell surface expression of scavenger receptor SR-BI. | 2011 Jul 1 |
1 |
| 12 |
20371703 | A novel bile acid-activated vitamin D receptor signaling in human hepatocytes. | 2010 Jun |
1 |
| 13 |
19098277 | Identification of replication-competent HSV-1 Cgal+ strain signaling targets in human hepatoma cells by functional organelle proteomics. | 2009 Apr |
1 |
| 14 |
18056704 | mTORC1 signaling can regulate growth factor activation of p44/42 mitogen-activated protein kinases through protein phosphatase 2A. | 2008 Feb 1 |
1 |
| 15 |
18204781 | Phosphorylation and nuclear translocation of STAT3 regulated by the Epstein-Barr virus latent membrane protein 1 in nasopharyngeal carcinoma. | 2008 Feb |
1 |
| 16 |
18245498 | Raf and MEK protein kinases are direct molecular targets for the chemopreventive effect of quercetin, a major flavonol in red wine. | 2008 Feb 1 |
1 |
| 17 |
18424438 | NF-kappaB-dependent transcriptional activation in lung carcinoma cells by farnesol involves p65/RelA(Ser276) phosphorylation via the MEK-MSK1 signaling pathway. | 2008 Jun 13 |
5 |
| 18 |
18593598 | WNK2 modulates MEK1 activity through the Rho GTPase pathway. | 2008 Oct |
1 |
| 19 |
18596912 | PPARgamma and MEK Interactions in Cancer. | 2008 |
1 |
| 20 |
18632853 | ERK1/2-mediated phosphorylation of small hepatitis delta antigen at serine 177 enhances hepatitis delta virus antigenomic RNA replication. | 2008 Oct |
2 |
| 21 |
18662673 | Thalidomide inhibits epidermal growth factor-induced cell growth in mouse and human monocytic leukemia cells via Ras inactivation. | 2008 Oct 3 |
1 |
| 22 |
18694962 | Serum-induced phosphorylation of the serum response factor coactivator MKL1 by the extracellular signal-regulated kinase 1/2 pathway inhibits its nuclear localization. | 2008 Oct |
1 |
| 23 |
17055484 | c-jun amino-terminal kinase and mitogen activated protein kinase 1/2 mediate hepatocyte growth factor-induced migration of brain endothelial cells. | 2007 Jan 1 |
1 |
| 24 |
17314031 | MEK1 activation by PAK: a novel mechanism. | 2007 Jul |
5 |
| 25 |
17667937 | Protein kinase WNK2 inhibits cell proliferation by negatively modulating the activation of MEK1/ERK1/2. | 2007 Sep 6 |
1 |
| 26 |
16169661 | Protein kinase C alpha trigger Ras and Raf-independent MEK/ERK activation for TPA-induced growth inhibition of human hepatoma cell HepG2. | 2006 Jul 28 |
1 |
| 27 |
16286470 | Cooperation of ERK and SCFSkp2 for MKP-1 destruction provides a positive feedback regulation of proliferating signaling. | 2006 Jan 13 |
4 |
| 28 |
16815847 | Peroxisome proliferator-activated receptor gamma promotes epithelial to mesenchymal transformation by Rho GTPase-dependent activation of ERK1/2. | 2006 Aug 25 |
2 |
| 29 |
15728510 | The production of IL-1 receptor antagonist in IFN-beta-stimulated human monocytes depends on the activation of phosphatidylinositol 3-kinase but not of STAT1. | 2005 Mar 1 |
1 |
| 30 |
16129686 | Role of group A p21-activated kinases in activation of extracellular-regulated kinase by growth factors. | 2005 Nov 4 |
4 |
| 31 |
16239230 | Positive regulation of Raf1-MEK1/2-ERK1/2 signaling by protein serine/threonine phosphatase 2A holoenzymes. | 2005 Dec 30 |
1 |
| 32 |
12571252 | Fibroblast growth factor-2-induced signaling through lipid raft-associated fibroblast growth factor receptor substrate 2 (FRS2). | 2003 Apr 18 |
1 |
| 33 |
11948406 | PAK1 primes MEK1 for phosphorylation by Raf-1 kinase during cross-cascade activation of the ERK pathway. | 2002 Mar 28 |
1 |
| 34 |
12006497 | Signaling disrupts mSin3A binding to the Mad1-like Sin3-interacting domain of TIEG2, an Sp1-like repressor. | 2002 May 15 |
1 |
| 35 |
12244094 | Phosphorylation of 338SSYY341 regulates specific interaction between Raf-1 and MEK1. | 2002 Nov 22 |
1 |
| 36 |
11342545 | Endothelin-1 induces serine phosphorylation of the adaptor protein p66Shc and its association with 14-3-3 protein in glomerular mesangial cells. | 2001 Jul 13 |
3 |
| 37 |
11581189 | Glial cell-derived neurotrophic factor (GDNF)-induced migration and signal transduction in corneal epithelial cells. | 2001 Oct |
1 |
| 38 |
11585926 | The transcription factor GATA4 is activated by extracellular signal-regulated kinase 1- and 2-mediated phosphorylation of serine 105 in cardiomyocytes. | 2001 Nov |
4 |
| 39 |
10645003 | Inhibition of collagenase-3 (MMP-13) expression in transformed human keratinocytes by interferon-gamma is associated with activation of extracellular signal-regulated kinase-1,2 and STAT1. | 2000 Jan 13 |
2 |
| 40 |
10828601 | Chromosome mapping of the human genes encoding the MAP kinase kinase MEK1 (MAP2K1) to 15q21 and MEK2 (MAP2K2) to 7q32. | 2000 |
1 |
| 41 |
11042690 | A novel assay for the measurement of Raf-1 kinase activity. | 2000 Oct 12 |
2 |
| 42 |
11043572 | Tumor necrosis factor alpha-mediated insulin resistance, but not dedifferentiation, is abrogated by MEK1/2 inhibitors in 3T3-L1 adipocytes. | 2000 Oct |
1 |
| 43 |
9430728 | Feedback regulation of Raf-1 and mitogen-activated protein kinase (MAP) kinase kinases 1 and 2 by MAP kinase phosphatase-1 (MKP-1). | 1998 Jan 16 |
1 |
| 44 |
9416003 | Identification and characterization of an auto-activating MEK kinase from bovine brain: phosphorylation of serine-298 in the proline-rich domain of the mammalian MEKs. | 1997 Aug-Sep |
1 |
| 45 |
8621729 | Selective activation of MEK1 but not MEK2 by A-Raf from epidermal growth factor-stimulated Hela cells. | 1996 Feb 9 |
1 |
| 46 |
8034695 | Chemotactic peptides induce phosphorylation and activation of MEK-1 in human neutrophils. | 1994 Jul 29 |
2 |
| 47 |
8039496 | Constitutive mutant and putative regulatory serine phosphorylation site of mammalian MAP kinase kinase (MEK1). | 1994 Jul 1 |
1 |
| 48 |
8131746 | Activation of MEK family kinases requires phosphorylation of two conserved Ser/Thr residues. | 1994 Mar 1 |
3 |