U 0126

mitogen-activated protein kinase kinase 1 ; Homo sapiens







436 Article(s)
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1 34974790 NCAPH promotes cell proliferation and inhibits cell apoptosis of bladder cancer cells through MEK/ERK signaling pathway. 2022 Feb 1
2 32914311 Mitogen-activated protein kinases are involved in cucurbitacin D-induced antitumor effects on adult T-cell leukemia cells. 2021 Feb 1
3 33574243 PLAU directs conversion of fibroblasts to inflammatory cancer-associated fibroblasts, promoting esophageal squamous cell carcinoma progression via uPAR/Akt/NF-κB/IL8 pathway. 2021 Feb 11 1
4 34273373 PBDEs affect inflammatory and oncosuppressive mechanisms via the EZH2 methyltransferase in airway epithelial cells. 2021 Oct 1 1
5 34451823 Pitavastatin Is a Highly Potent Inhibitor of T-Cell Proliferation. 2021 Jul 27 1
6 34873481 MEK1/2 regulates APOBEC3B and polymerase iota-induced mutagenesis in head and neck cancer cells. 2021 1
7 31881249 A1CF-promoted colony formation and proliferation of RCC depends on DKK1-MEK/ERK signal axis. 2020 Mar 10 1
8 32339486 Identification and characterization of human PEIG-1/GPRC5A as a 12-O-tetradecanoyl phorbol-13-acetate (TPA) and PKC-induced gene. 2020 Jul 15 2
9 32414345 Upregulation of pERK and c-JUN by γ-tocotrienol and not α-tocopherol are essential to the differential effect on apoptosis in prostate cancer cells. 2020 May 15 1
10 32602013 Speedy/RINGO protein interacts with ERK/MAPK and PI3K/AKT pathways in SH-SY5Y neuroblastoma cells. 2020 Oct 1
11 32606806 SSPH I, a Novel Anti-Cancer Saponin, Inhibits Autophagy and Induces Apoptosis via ROS Accumulation and ERK1/2 Signaling Pathway in Hepatocellular Carcinoma Cells. 2020 1
12 32692865 Tight junction protein claudin-1 is downregulated by TGF-β1 via MEK signaling in benign prostatic epithelial cells. 2020 Oct 1
13 32843616 IGF-1R inhibition induces MEK phosphorylation to promote survival in colon carcinomas. 2020 Aug 26 2
14 32950025 Regulators of thymic stromal lymphopoietin production by human adipocytes. 2020 Dec 1
15 33209885 Blocking MAPK/ERK pathway sensitizes hepatocellular carcinoma cells to temozolomide via downregulating MGMT expression. 2020 Oct 1
16 33374849 Involvement of the ERK/HIF-1α/EMT Pathway in XCL1-Induced Migration of MDA-MB-231 and SK-BR-3 Breast Cancer Cells. 2020 Dec 23 1
17 30255656 Knockdown of PEBP4 inhibits human glioma cell growth and invasive potential via ERK1/2 signaling pathway. 2019 Jan 1
18 30365943 A novel role for CRIM1 in the corneal response to UV and pterygium development. 2019 Feb 1
19 30535504 MEK inhibitor enhanced the antitumor effect of oxaliplatin and 5‑fluorouracil in MEK1 Q56P‑mutant colorectal cancer cells. 2019 Feb 1
20 30654768 Podoplanin (PDPN) affects the invasiveness of thyroid carcinoma cells by inducing ezrin, radixin and moesin (E/R/M) phosphorylation in association with matrix metalloproteinases. 2019 Jan 17 1
21 30712236 Letrozole improves the sensitivity of breast cancer cells overexpressing aromatase to cisplatin via down-regulation of FEN1. 2019 Aug 1
22 30730256 Involvement of ERK1/2-mediated ELK1/CHOP/DR5 pathway in 6-(methylsulfinyl)hexyl isothiocyanate-induced apoptosis of colorectal cancer cells. 2019 May 1
23 30971268 Targeting p21-activated kinase 1 inhibits growth and metastasis via Raf1/MEK1/ERK signaling in esophageal squamous cell carcinoma cells. 2019 Apr 11 1
24 31068539 Titanium dioxide nanoparticles induce COX-2 expression through ROS generation in human periodontal ligament cells. 2019 1
25 31227218 Muscarinic acetylcholine receptors regulate the dephosphorylation of eukaryotic translation elongation factor 2 in SNU-407 colon cancer cells. 2019 Aug 20 1
26 31322183 CXCL1 stimulates migration and invasion in ER‑negative breast cancer cells via activation of the ERK/MMP2/9 signaling axis. 2019 Sep 1
27 31329883 Phosphorylation of TMEM55B by Erk/MAPK regulates lysosomal positioning. 2019 Aug 1 1
28 31874951 Elevated Expression of NOTCH1 Associates with Lymph Node Metastasis of Gastric Cancer and Knock-Down of NOTCH1 Attenuates Tumor Cell Progression. 2019 Dec 25 1
29 29208568 Overexpression of ELF3 facilitates cell growth and metastasis through PI3K/Akt and ERK signaling pathways in non-small cell lung cancer. 2018 Jan 1
30 29467389 Long glucocorticoid-induced leucine zipper regulates human thyroid cancer cell proliferation. 2018 Feb 21 1
31 29552216 lncRNA BANCR promotes EMT in PTC via the Raf/MEK/ERK signaling pathway. 2018 Apr 1
32 29928931 Oxytocin alters the morphology of hypothalamic neurons via the transcription factor myocyte enhancer factor 2A (MEF-2A). 2018 Dec 5 1
33 30034315 Investigating the effect of visfatin on ERalpha phosphorylation (Ser118 and Ser167) and ERE-dependent transcriptional activity. 2018 1
34 27734226 C1ql1/Ctrp14 and C1ql4/Ctrp11 promote angiogenesis of endothelial cells through activation of ERK1/2 signal pathway. 2017 Jan 1
35 27852823 Phosphorylation of Human Retinoid X Receptor α at Serine 260 Impairs Its Subcellular Localization, Receptor Interaction, Nuclear Mobility, and 1α,25-Dihydroxyvitamin D3-dependent DNA Binding in Ras-transformed Keratinocytes. 2017 Jan 27 1
36 28223944 IL-1β-Induced Downregulation of the Multifunctional PDZ Adaptor PDZK1 Is Attenuated by ERK Inhibition, RXRα, or PPARα Stimulation in Enterocytes. 2017 1
37 28281844 CXCR7 as a chemokine receptor for SDF-1 promotes gastric cancer progression via MAPK pathways. 2017 Jun - Jul 1
38 28286738 TSC2/Rheb signaling mediates ERK-dependent regulation of mTORC1 activity in C2C12 myoblasts. 2017 Mar 1
39 28288823 Cadmium-induced IL-6 and IL-8 expression and release from astrocytes are mediated by MAPK and NF-κB pathways. 2017 May 1
40 28385507 Discovery of a cobalt complex with high MEK1 binding affinity. 2017 May 15 1
41 28492136 Inhibition of ERK1/2 Signaling Impairs the Promoting Effects of TGF-β1 on Hepatocellular Carcinoma Cell Invasion and Epithelial-Mesenchymal Transition. 2017 Nov 2 1
42 28501331 The expression of keratin 6 is regulated by the activation of the ERK1/2 pathway in arsenite transformed human urothelial cells. 2017 Sep 15 1
43 28959141 Blocking ERK1/2 signaling impairs TGF-β1 tumor promoting function but enhances its tumor suppressing role in intrahepatic cholangiocarcinoma cells. 2017 1
44 29061787 (-)-Epigallocatechin-3-gallate Down-regulates Doxorubicin-induced Overexpression of P-glycoprotein Through the Coordinate Inhibition of PI3K/Akt and MEK/ERK Signaling Pathways. 2017 Nov 1
45 25421211 Location- and Subunit-Specific NMDA Receptors Determine the Developmental Sevoflurane Neurotoxicity Through ERK1/2 Signaling. 2016 Jan 1
46 26111538 MWCNTs Induce ROS Generation, ERK Phosphorylation, and SOD-2 Expression in Human Mesothelial Cells. 2016 Jan-Feb 1
47 26483408 Activation of the Classical Mitogen-Activated Protein Kinases Is Part of the Shiga Toxin-Induced Ribotoxic Stress Response and May Contribute to Shiga Toxin-Induced Inflammation. 2016 Jan 1
48 26537583 MEK-dependent IL-8 induction regulates the invasiveness of triple-negative breast cancer cells. 2016 Apr 1
49 26566727 TGFβ1 regulates Scleraxis expression in primary cardiac myofibroblasts by a Smad-independent mechanism. 2016 Jan 15 1
50 26581032 Distinction Between Cell Proliferation and Apoptosis Signals Regulated by Brain-Derived Neurotrophic Factor in Human Periodontal Ligament Cells and Gingival Epithelial Cells. 2016 Jul 1