palbociclib

estrogen receptor 1 ; Homo sapiens







35 Article(s)
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1 35164144 Conjugation of Palbociclib with MHI-148 Has an Increased Cytotoxic Effect for Breast Cancer Cells and an Altered Mechanism of Action. 2022 Jan 27 2
2 35241469 Randomised, open-label, multicentric phase III trial to evaluate the safety and efficacy of palbociclib in combination with endocrine therapy, guided by ESR1 mutation monitoring in oestrogen receptor-positive, HER2-negative metastatic breast cancer patients: study design of PADA-1. 2022 Mar 3 1
3 35350768 The Resistance of Cancer Cells to Palbociclib, a Cyclin-Dependent Kinase 4/6 Inhibitor, is Mediated by the ABCB1 Transporter. 2022 1
4 33356791 Sustained mTORC1 activity during palbociclib-induced growth arrest triggers senescence in ER+ breast cancer cells. 2021 Jan 1
5 33407601 Genomic profile of metastatic breast cancer patient-derived xenografts established using percutaneous biopsy. 2021 Jan 6 1
6 33676547 Circulating tumor DNA as a dynamic biomarker of response to palbociclib and fulvestrant in metastatic breast cancer patients. 2021 Mar 6 1
7 33835229 Pharmacokinetics, safety, activity, and biomarker analysis of palbociclib plus letrozole as first-line treatment for ER+/HER2- advanced breast cancer in Chinese women. 2021 Jul 1
8 34244855 The mechanisms involved in the resistance of estrogen receptor-positive breast cancer cells to palbociclib are multiple and change over time. 2021 Nov 2
9 34388698 Efficacy and safety of palbociclib in patients with estrogen receptor-positive/human epidermal growth factor receptor 2-negative advanced breast cancer with preexisting conditions: A post hoc analysis of PALOMA-2. 2021 Oct 1
10 34657057 [Successful Treatment of Estrogen Receptor Positive, HER2 Negative Breast Cancer with Life-Threatening Multiple Bone Metastases Using the Combination of Fulvestrant and Palbociclib-A Case Report]. 2021 Oct 2
11 31649043 FDA Approval Summary: Palbociclib for Male Patients with Metastatic Breast Cancer. 2020 Mar 15 1
12 32130619 G1T48, an oral selective estrogen receptor degrader, and the CDK4/6 inhibitor lerociclib inhibit tumor growth in animal models of endocrine-resistant breast cancer. 2020 Apr 3
13 32164162 Glucose Metabolic Reprogramming of ER Breast Cancer in Acquired Resistance to the CDK4/6 Inhibitor Palbociclib. 2020 Mar 10 1
14 32453591 Novel Pyrrolopyridone Bromodomain and Extra-Terminal Motif (BET) Inhibitors Effective in Endocrine-Resistant ER+ Breast Cancer with Acquired Resistance to Fulvestrant and Palbociclib. 2020 Jul 9 1
15 32723837 Acquired FGFR and FGF Alterations Confer Resistance to Estrogen Receptor (ER) Targeted Therapy in ER+ Metastatic Breast Cancer. 2020 Nov 15 1
16 32938620 Palbociclib and Trastuzumab in HER2-Positive Advanced Breast Cancer: Results from the Phase II SOLTI-1303 PATRICIA Trial. 2020 Nov 15 1
17 30523750 Randomized Phase II Study Evaluating Palbociclib in Addition to Letrozole as Neoadjuvant Therapy in Estrogen Receptor-Positive Early Breast Cancer: PALLET Trial. 2019 Jan 20 2
18 30745839 Combined Androgen receptor blockade overcomes the resistance of breast cancer cells to palbociclib. 2019 1
19 30772267 Palbociclib triggers apoptosis in bladder cancer cells by Cdk2-induced Rad9-mediated reorganization of the Bak.Bcl-xl complex. 2019 May 1
20 30867218 Combined Inhibition of STAT3 and DNA Repair in Palbociclib-Resistant ER-Positive Breast Cancer. 2019 Jul 1 1
21 31217344 Palbociclib with Letrozole in Postmenopausal Women with ER+/HER2- Advanced Breast Cancer: Hematologic Safety Analysis of the Randomized PALOMA-2 Trial. 2019 Dec 2
22 31330844 Palbociclib Promotes Dephosphorylation of NPM/B23 at Threonine 199 and Inhibits Endometrial Cancer Cell Growth. 2019 Jul 20 1
23 31371343 FGFR1 Amplification Mediates Endocrine Resistance but Retains TORC Sensitivity in Metastatic Hormone Receptor-Positive (HR+) Breast Cancer. 2019 Nov 1 1
24 31640597 Palbociclib in combination with simvastatin induce severe rhabdomyolysis: a case report. 2019 Oct 22 1
25 29337187 Metabolomics Reveals that Dietary Xenoestrogens Alter Cellular Metabolism Induced by Palbociclib/Letrozole Combination Cancer Therapy. 2018 Mar 15 2
26 29893790 Palbociclib as single agent or in combination with the endocrine therapy received before disease progression for estrogen receptor-positive, HER2-negative metastatic breast cancer: TREnd trial. 2018 Aug 1 1
27 30069766 Palbociclib-The First of a New Class of Cell Cycle Inhibitors. 2018 1
28 28856074 Utilizing Tumor and Plasma Liquid Biopsy in Treatment Decision Making for an Estrogen Receptor-Positive Advanced Breast Cancer Patient. 2017 Jun 29 2
29 28978004 Detection of ESR1 mutations in circulating cell-free DNA from patients with metastatic breast cancer treated with palbociclib and letrozole. 2017 Sep 15 1
30 29261702 Combination of palbociclib with enzalutamide shows in vitro activity in RB proficient and androgen receptor positive triple negative breast cancer cells. 2017 2
31 26857361 Targeting the cyclin-dependent kinases (CDK) 4/6 in estrogen receptor-positive breast cancers. 2016 Feb 9 1
32 27009458 Hyperuricemia in 2 Patients Receiving Palbociclib for Breast Cancer. 2016 Jan 3
33 27274308 Profile of palbociclib in the treatment of metastatic breast cancer. 2016 1
34 27785059 Impact of palbociclib combinations on treatment of advanced estrogen receptor-positive/human epidermal growth factor 2-negative breast cancer. 2016 1
35 26324739 FDA Approval: Palbociclib for the Treatment of Postmenopausal Patients with Estrogen Receptor-Positive, HER2-Negative Metastatic Breast Cancer. 2015 Nov 1 1