4,17 beta-dihydroxy-4-androstene-3-one

estrogen receptor 1 ; Homo sapiens







36 Article(s)
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1 35263700 Acetyl-CoA synthetases ACSS1 and ACSS2 are 4-hydroxytamoxifen responsive factors that promote survival in tamoxifen treated and estrogen deprived cells. 2022 May 2
2 34244306 Exploiting off-target effects of estrogen deprivation to sensitize estrogen receptor negative breast cancer to immune killing. 2021 Jul 5
3 34572047 Inhibition of Metabolism as a Therapeutic Option for Tamoxifen-Resistant Breast Cancer Cells. 2021 Sep 12 3
4 34957309 In Silico Screening of Marine Compounds as an Emerging and Promising Approach against Estrogen Receptor Alpha-Positive Breast Cancer. 2021 2
5 29557271 Structural insight into the antagonistic action of diarylheptanoid on human estrogen receptor alpha. 2019 Mar 1
6 31670920 EGFR is a Therapeutic Target in Hormone Receptor-Positive Breast Cancer. 2019 1
7 29237052 Multimode drug inducible CRISPR/Cas9 devices for transcriptional activation and genome editing. 2018 Mar 16 1
8 29632071 The F domain of estrogen receptor α is involved in species-specific, tamoxifen-mediated transactivation. 2018 Jun 1 1
9 30208932 Nogo-B receptor increases the resistance to tamoxifen in estrogen receptor-positive breast cancer cells. 2018 Sep 12 1
10 30614492 Detecting the Ligand-binding Domain Dimerization Activity of Estrogen Receptor Alpha Using the Mammalian Two-Hybrid Assay. 2018 Dec 19 1
11 33418733 Controlled Three-Dimensional Tumor Microenvironments Recapitulate Phenotypic Features and Differential Drug Response in Early vs Advanced Stage Breast Cancer. 2018 Feb 12 1
12 27159275 A Novel Combinatorial Epigenetic Therapy Using Resveratrol and Pterostilbene for Restoring Estrogen Receptor-α (ERα) Expression in ERα-Negative Breast Cancer Cells. 2016 3
13 25279503 Bioenergetic differences between MCF-7 and T47D breast cancer cells and their regulation by oestradiol and tamoxifen. 2015 Jan 1 1
14 25014417 Identification of coregulators influenced by estrogen receptor subtype specific binding of the ER antagonists 4-hydroxytamoxifen and fulvestrant. 2014 Sep 5 1
15 25064027 Promoting E2F1-mediated apoptosis in oestrogen receptor-α-negative breast cancer cells. 2014 Jul 26 2
16 23704208 c-Src modulates estrogen-induced stress and apoptosis in estrogen-deprived breast cancer cells. 2013 Jul 15 1
17 23892277 Estradiol and tamoxifen regulate NRF-1 and mitochondrial function in mouse mammary gland and uterus. 2013 Oct 2
18 19858209 G protein pathway suppressor 2 (GPS2) is a transcriptional corepressor important for estrogen receptor alpha-mediated transcriptional regulation. 2009 Dec 25 2
19 18499701 Epigenetic repression of the estrogen-regulated Homeobox B13 gene in breast cancer. 2008 Jul 1
20 18001325 Agonist activity of the 3-hydroxy metabolites of tibolone through the oestrogen receptor in the mouse N20.1 oligodendrocyte cell line and normal human astrocytes. 2007 Dec 1
21 14715875 Differential recruitment of coregulator proteins steroid receptor coactivator-1 and silencing mediator for retinoid and thyroid receptors to the estrogen receptor-estrogen response element by beta-estradiol and 4-hydroxytamoxifen in human breast cancer. 2004 Jan 2
22 15297425 Mifepristone induces growth arrest, caspase activation, and apoptosis of estrogen receptor-expressing, antiestrogen-resistant breast cancer cells. 2004 Aug 1 1
23 15457130 Tamoxifen and epigallocatechin gallate are synergistically cytotoxic to MDA-MB-231 human breast cancer cells. 2004 Oct 2
24 12648521 17 beta-estradiol- and 4-hydroxytamoxifen-induced transactivation in breast, endometrial and liver cancer cells is dependent on ER-subtype, cell and promoter context. 2003 Jan 2
25 12495475 Estrogen receptor expression and estrogen receptor-independent cytotoxic effects of tamoxifen on malignant rhabdoid tumor cells in vitro. 2002 Dec 2
26 11306182 Estrogen response element sequence impacts the conformation and transcriptional activity of estrogen receptor alpha. 2001 Mar 28 1
27 11325832 Silencing and reactivation of the selective estrogen receptor modulator-estrogen receptor alpha complex. 2001 May 1 1
28 11530283 Estrogen receptor alpha mediated induction of the transforming growth factor alpha gene by estradiol and 4-hydroxytamoxifen in MDA-MB-231 breast cancer cells. 2001 Jul 3
29 11719281 Estrogen response element binding induces alterations in estrogen receptor-alpha conformation as revealed by susceptibility to partial proteolysis. 2001 Dec 4
30 10418989 Suppression of gene expression by tethering KRAB domain to promoter of ER target genes. 1999 Apr-Jun 1
31 9566718 Agonist activity of antiestrogen-receptor complexes to regulate urokinase plasminogen activator (uPA) and plasminogen activator inhibitor type 1 (PAI-1) endogenous gene expression in breast cancer cells. 1998 Mar 13 2
32 9806352 Comparison of tamoxifen ligands on estrogen receptor interaction with estrogen response elements. 1998 Aug 25 3
33 8738832 Site-directed estrogen receptor antibodies stabilize 4-hydroxytamoxifen ligand, but not estradiol, and indicate ligand-specific differences in the recognition of estrogen response element DNA in vitro. 1996 May 1
34 8809185 Footprint analysis of estrogen receptor binding to adjacent estrogen response elements. 1996 Apr 5
35 7873531 Cooperative binding of estrogen receptor to DNA depends on spacing of binding sites, flanking sequence, and ligand. 1995 Feb 28 6
36 1491696 Point mutation of estrogen receptor (ER) in the ligand-binding domain changes the pharmacology of antiestrogens in ER-negative breast cancer cells stably expressing complementary DNAs for ER. 1992 Dec 3