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35318866 | Aldehyde dehydrogenase 2 deficiency promotes skeletal muscle atrophy in aged mice. | 2022 Jun 1 |
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33208242 | Transformed ALDH2-/- hepatocytes by ethanol could serve as a useful tool for studying alcoholic hepatocarcinogenesis. | 2021 Jan |
4 |
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33740503 | Acetaldehyde Dehydrogenase 2 regulates HMG-CoA reductase stability and cholesterol synthesis in the liver. | 2021 May |
2 |
| 4 |
34211048 | Acetaldehyde exposure underlies functional defects in monocytes induced by excessive alcohol consumption. | 2021 Jul 1 |
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| 5 |
34228649 | Aldehyde dehydrogenase 2 protects against acute kidney injury by regulating autophagy via the Beclin-1 pathway. | 2021 Aug 9 |
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34439969 | Aldehyde Dehydrogenase Mutation Exacerbated High-Fat-Diet-Induced Nonalcoholic Fatty Liver Disease with Gut Microbiota Remodeling in Male Mice. | 2021 Aug 1 |
3 |
| 7 |
31074772 | Protective effects of Alda-1, an ALDH2 activator, on alcohol-derived DNA damage in the esophagus of human ALDH2*2 (Glu504Lys) knock-in mice. | 2020 Apr 22 |
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31801381 | Systemic Adeno-Associated Virus-Mediated Gene Therapy Prevents the Multiorgan Disorders Associated with Aldehyde Dehydrogenase 2 Deficiency and Chronic Ethanol Ingestion. | 2020 Feb |
2 |
| 9 |
32059264 | Aldehyde dehydrogenase 2 deficiency significantly exacerbates tert-butyl alcohol-induced toxicity in mice. | 2020 Jul |
2 |
| 10 |
32062779 | High Ethanol and Acetaldehyde Inhibit Glutamatergic Transmission in the Hippocampus of Aldh2-Knockout and C57BL/6N Mice: an In Vivo and Ex Vivo Analysis. | 2020 Mar |
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| 11 |
32151565 | 6-(Methylsulfinyl)hexyl isothiocyanate protects acetaldehyde-caused cytotoxicity through the induction of aldehyde dehydrogenase in hepatocytes. | 2020 Jun 15 |
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32325250 | Disruption of the aldehyde dehydrogenase 2 gene increases the bone anabolic response to intermittent PTH treatment in an ovariectomized mouse model. | 2020 Jul |
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| 13 |
32403082 | Novel and prevalent non-East Asian ALDH2 variants; Implications for global susceptibility to aldehydes' toxicity. | 2020 May |
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| 14 |
32576773 | High ethanol and acetaldehyde decrease extracellular glutamate in the frontal cortex of freely moving mice. | 2020 Jun 22 |
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| 15 |
32896553 | A critical assessment of the potential of pharmacological modulation of aldehyde dehydrogenases to treat the diseases of bone loss. | 2020 Nov 5 |
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| 16 |
30121625 | Alcohol inhibits T-cell glucose metabolism and hepatitis in ALDH2-deficient mice and humans: roles of acetaldehyde and glucocorticoids. | 2019 Jul |
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| 17 |
30375985 | Acetaldehyde dehydrogenase 2 interactions with LDLR and AMPK regulate foam cell formation. | 2019 Jan 2 |
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| 18 |
30721697 | Ethanol induces skin hyperpigmentation in mice with aldehyde dehydrogenase 2 deficiency. | 2019 Apr 1 |
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| 19 |
31279903 | ALDH2 deficiency promotes alcohol-associated liver cancer by activating oncogenic pathways via oxidized DNA-enriched extracellular vesicles. | 2019 Nov |
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| 20 |
31649957 | Gene Therapy Correction of Aldehyde Dehydrogenase 2 Deficiency. | 2019 Dec 13 |
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| 21 |
31792171 | Targeting liver aldehyde dehydrogenase-2 prevents heavy but not moderate alcohol drinking. | 2019 Dec 17 |
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31829281 | Aldehyde dehydrogenase 2 activity and aldehydic load contribute to neuroinflammation and Alzheimer's disease related pathology. | 2019 Dec 12 |
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29156373 | Mitochondria-targeted ubiquinone (MitoQ) enhances acetaldehyde clearance by reversing alcohol-induced posttranslational modification of aldehyde dehydrogenase 2: A molecular mechanism of protection against alcoholic liver disease. | 2018 Apr |
5 |
| 24 |
29482068 | Cortical bone loss due to skeletal unloading in aldehyde dehydrogenase 2 gene knockout mice is associated with decreased PTH receptor expression in osteocytes. | 2018 May |
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| 25 |
29579152 | Cardioprotection induced by a brief exposure to acetaldehyde: role of aldehyde dehydrogenase 2. | 2018 Jun 1 |
7 |
| 26 |
29859945 | The murine hepatic sequelae of long-term ethanol consumption are sex-specific and exacerbated by Aldh1b1 loss. | 2018 Aug |
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| 27 |
30036570 | Acetaldehyde administration induces salsolinol formation in vivo in the dorsal striatum of Aldh2-knockout and C57BL/6N mice. | 2018 Oct 15 |
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| 28 |
27840306 | Aldehyde dehydrogenase 2 deficiency negates chronic low-to-moderate alcohol consumption-induced cardioprotecion possibly via ROS-dependent apoptosis and RIP1/RIP3/MLKL-mediated necroptosis. | 2017 Aug |
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| 29 |
28027570 | Aldehyde dehydrogenase-2 (ALDH2) opposes hepatocellular carcinoma progression by regulating AMP-activated protein kinase signaling in mice. | 2017 May |
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| 30 |
28249782 | ALDH2 restores exhaustive exercise-induced mitochondrial dysfunction in skeletal muscle. | 2017 Apr 15 |
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| 31 |
28500264 | S1P receptor 1-Mediated Anti-Renin-Angiotensin System Cardioprotection: Pivotal Role of Mast Cell Aldehyde Dehydrogenase Type 2. | 2017 Aug |
2 |
| 32 |
28532411 | Aldehyde dehydrogenase 2*2 knock-in mice show increased reactive oxygen species production in response to cisplatin treatment. | 2017 May 22 |
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| 33 |
26646001 | Ethanol and Acetaldehyde After Intraperitoneal Administration to Aldh2-Knockout Mice-Reflection in Blood and Brain Levels. | 2016 May |
8 |
| 34 |
26711020 | Ethanol and acetaldehyde differentially alter extracellular dopamine and serotonin in Aldh2-knockout mouse dorsal striatum: A reverse microdialysis study. | 2016 Jan |
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| 35 |
27186430 | ALDH2 modulates autophagy flux to regulate acetaldehyde-mediated toxicity thresholds. | 2016 |
4 |
| 36 |
27575855 | PKC-ALDH2 Pathway Plays a Novel Role in Adipocyte Differentiation. | 2016 |
2 |
| 37 |
25713355 | Pharmacological recruitment of aldehyde dehydrogenase 3A1 (ALDH3A1) to assist ALDH2 in acetaldehyde and ethanol metabolism in vivo. | 2015 Mar 10 |
5 |
| 38 |
26374466 | Protective role of ALDH2 against acetaldehyde-derived DNA damage in oesophageal squamous epithelium. | 2015 Sep 16 |
8 |
| 39 |
24448831 | Assessment of the reproductive toxicity of inhalation exposure to ethyl tertiary butyl ether in male mice with normal, low active and inactive ALDH2. | 2014 Apr |
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| 40 |
24492981 | Aldehyde dehydrogenase 2 deficiency ameliorates alcoholic fatty liver but worsens liver inflammation and fibrosis in mice. | 2014 Jul |
3 |
| 41 |
24959382 | Impairment of aldehyde dehydrogenase 2 increases accumulation of acetaldehyde-derived DNA damage in the esophagus after ethanol ingestion. | 2014 |
6 |
| 42 |
25084483 | Rutin attenuates ethanol-induced neurotoxicity in hippocampal neuronal cells by increasing aldehyde dehydrogenase 2. | 2014 Oct |
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| 43 |
25163478 | Aldehyde dehydrogenase-2 regulates nociception in rodent models of acute inflammatory pain. | 2014 Aug 27 |
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| 44 |
23313283 | Disruption of aldehyde dehydrogenase 2 gene results in altered cortical bone structure and increased cortical bone mineral density in the femoral diaphysis of mice. | 2013 Apr |
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24096209 | Ethanol- and acetaldehyde-induced cholinergic imbalance in the hippocampus of Aldh2-knockout mice does not affect nerve growth factor or brain-derived neurotrophic factor. | 2013 Nov 20 |
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| 46 |
22361447 | High ethanol and acetaldehyde impair spatial memory in mouse models: opposite effects of aldehyde dehydrogenase 2 and apolipoprotein E on memory. | 2012 May |
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| 47 |
22451246 | Effects and action mechanisms of Korean pear (Pyrus pyrifolia cv. Shingo) on alcohol detoxification. | 2012 Nov |
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| 48 |
22508505 | Aldehyde-stress resulting from Aldh2 mutation promotes osteoporosis due to impaired osteoblastogenesis. | 2012 Sep |
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22922648 | Genotoxic consequences of endogenous aldehydes on mouse haematopoietic stem cell function. | 2012 Sep 27 |
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| 50 |
21734703 | Fancd2 counteracts the toxic effects of naturally produced aldehydes in mice. | 2011 Jul 6 |
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