| 1 |
35127383 | Identification of a novel PHGDH covalent inhibitor by chemical proteomics and phenotypic profiling. | 2022 Jan |
2 |
| 2 |
35143932 | Vitamin C promotes anti-leukemia of DZNep in acute myeloid leukemia. | 2022 May 1 |
2 |
| 3 |
35165259 | De novo serine synthesis regulates chondrocyte proliferation during bone development and repair. | 2022 Feb 15 |
10 |
| 4 |
35235889 | Discovery of PHGDH inhibitors by virtual screening and preliminary structure-activity relationship study. | 2022 Apr |
2 |
| 5 |
35354963 | ADH1C inhibits progression of colorectal cancer through the ADH1C/PHGDH /PSAT1/serine metabolic pathway. | 2022 Mar 30 |
1 |
| 6 |
35508106 | Glycolysis-derived L-serine levels versus PHGDH expression in Alzheimer's disease. | 2022 May 3 |
1 |
| 7 |
35594343 | Suppression of nuclear GSK3 signaling promotes serine/one-carbon metabolism and confers metabolic vulnerability in lung cancer cells. | 2022 May 20 |
1 |
| 8 |
35619118 | New molecular mechanisms in cholangiocarcinoma: signals triggering interleukin-6 production in tumor cells and KRAS co-opted epigenetic mediators driving metabolic reprogramming. | 2022 May 26 |
2 |
| 9 |
32940141 | Serine Metabolism Controls Dental Pulp Stem Cell Aging by Regulating the DNA Methylation of p16. | 2021 Jan |
1 |
| 10 |
33284994 | Inhibiting phosphoglycerate dehydrogenase counteracts chemotherapeutic efficacy against MYCN-amplified neuroblastoma. | 2021 Mar 1 |
2 |
| 11 |
33340488 | In Vivo Evidence for Serine Biosynthesis-Defined Sensitivity of Lung Metastasis, but Not of Primary Breast Tumors, to mTORC1 Inhibition. | 2021 Jan 21 |
1 |
| 12 |
33397437 | Targeting phosphoglycerate dehydrogenase in multiple myeloma. | 2021 Jan 4 |
2 |
| 13 |
33436370 | Serine Biosynthesis Is a Metabolic Vulnerability in FLT3-ITD-Driven Acute Myeloid Leukemia. | 2021 Jun |
1 |
| 14 |
33500247 | Serine Biosynthesis Is a Metabolic Vulnerability in IDH2-Driven Breast Cancer Progression. | 2021 Mar 15 |
1 |
| 15 |
33503424 | Metabolic compensation activates pro-survival mTORC1 signaling upon 3-phosphoglycerate dehydrogenase inhibition in osteosarcoma. | 2021 Jan 26 |
3 |
| 16 |
33526512 | Exogenous and Endogenous Sources of Serine Contribute to Colon Cancer Metabolism, Growth, and Resistance to 5-Fluorouracil. | 2021 May 1 |
2 |
| 17 |
33571419 | Phosphoglycerate dehydrogenase (PHGDH) inhibitors: a comprehensive review 2015-2020. | 2021 Jul |
2 |
| 18 |
33588715 | Phosphoserine Aminotransferase has Conserved Active Site from Microbes to Higher Eukaryotes with Minor Deviations. | 2021 |
2 |
| 19 |
33625616 | Prognostic significance of phosphoglycerate dehydrogenase in breast cancer. | 2021 Apr |
2 |
| 20 |
33735398 | 3-Phosphoglycerate dehydrogenase: a potential target for cancer treatment. | 2021 Jun |
2 |
| 21 |
33742121 | Energy stress-induced linc01564 activates the serine synthesis pathway and facilitates hepatocellular carcinogenesis. | 2021 Apr |
1 |
| 22 |
33753166 | Dimerization of PHGDH via the catalytic unit is essential for its enzymatic function. | 2021 Jan-Jun |
2 |
| 23 |
33758422 | Serine biosynthesis defect due to haploinsufficiency of PHGDH causes retinal disease. | 2021 Mar |
4 |
| 24 |
33792664 | INPP5K and SIL1 associated pathologies with overlapping clinical phenotypes converge through dysregulation of PHGDH. | 2021 Sep 4 |
1 |
| 25 |
33798471 | Serine metabolism antagonizes antiviral innate immunity by preventing ATP6V0d2-mediated YAP lysosomal degradation. | 2021 May 4 |
3 |
| 26 |
33921788 | Biochemical and Biophysical Characterization of Recombinant Human 3-Phosphoglycerate Dehydrogenase. | 2021 Apr 19 |
3 |
| 27 |
33931592 | Can small molecular inhibitors that stop de novo serine synthesis be used in cancer treatment? | 2021 Apr 30 |
2 |
| 28 |
34027041 | Targeting one-carbon metabolism requires mTOR inhibition: a new therapeutic approach in osteosarcoma. | 2021 Mar 25 |
2 |
| 29 |
34066864 | Characterization of ETFDH and PHGDH Mutations in a Patient with Mild Glutaric Aciduria Type II and Serine Deficiency. | 2021 May 8 |
3 |
| 30 |
34178629 | PHGDH Is Upregulated at Translational Level and Implicated in Platin-Resistant in Ovarian Cancer Cells. | 2021 |
1 |
| 31 |
34192988 | Inhibiting PHGDH with NCT-503 reroutes glucose-derived carbons into the TCA cycle, independently of its on-target effect. | 2021 Dec |
1 |
| 32 |
34298241 | Discovery of novel inhibitors of human phosphoglycerate dehydrogenase by activity-directed combinatorial chemical synthesis strategy. | 2021 Oct |
3 |
| 33 |
34508795 | Metabolic shift to serine biosynthesis through 3-PG accumulation and PHGDH induction promotes tumor growth in pancreatic cancer. | 2021 Dec 28 |
8 |
| 34 |
34663976 | The alternative activity of nuclear PHGDH contributes to tumour growth under nutrient stress. | 2021 Oct |
3 |
| 35 |
34720086 | Cul4A-DDB1-mediated monoubiquitination of phosphoglycerate dehydrogenase promotes colorectal cancer metastasis via increased S-adenosylmethionine. | 2021 Nov 1 |
4 |
| 36 |
34957102 | Hsa_circ_0062682 Promotes Serine Metabolism and Tumor Growth in Colorectal Cancer by Regulating the miR-940/PHGDH Axis. | 2021 |
4 |
| 37 |
34971423 | Biophysical and biochemical properties of PHGDH revealed by studies on PHGDH inhibitors. | 2021 Dec 31 |
1 |
| 38 |
32032680 | The PHGDH enigma: Do cancer cells only need serine or also a redox modulator? | 2020 Apr 28 |
2 |
| 39 |
32196970 | Clinical, molecular, and pathological findings in a Neu-Laxova syndrome stillborn: A Brazilian case report. | 2020 Jun |
1 |
| 40 |
32203214 | Serine-dependent redox homeostasis regulates glioblastoma cell survival. | 2020 Apr |
2 |
| 41 |
32226297 | The Role of D-3-Phosphoglycerate Dehydrogenase in Cancer. | 2020 |
3 |
| 42 |
32371575 | EWS-FLI1-regulated Serine Synthesis and Exogenous Serine are Necessary for Ewing Sarcoma Cellular Proliferation and Tumor Growth. | 2020 Jul |
3 |
| 43 |
32386122 | Characterization of PHGDH expression in bladder cancer: potential targeting therapy with gemcitabine/cisplatin and the contribution of promoter DNA hypomethylation. | 2020 Sep |
3 |
| 44 |
32420915 | Parkin on serine: a Parkinson disease gene suppresses serine synthesis in cancer. | 2020 Jun 1 |
2 |
| 45 |
32477466 | Apolipoprotein A-I anti-tumor activity targets cancer cell metabolism. | 2020 May 12 |
2 |
| 46 |
32478681 | Parkin ubiquitinates phosphoglycerate dehydrogenase to suppress serine synthesis and tumor progression. | 2020 Jun 1 |
7 |
| 47 |
32549981 | PHGDH supports liver ceramide synthesis and sustains lipid homeostasis. | 2020 |
2 |
| 48 |
32571778 | Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition. | 2020 Sep |
3 |
| 49 |
32581546 | Inhibition of Serine Metabolism Promotes Resistance to Cisplatin in Gastric Cancer. | 2020 |
2 |
| 50 |
32594192 | L-serine synthesis via the phosphorylated pathway in humans. | 2020 Dec |
1 |