| 1 |
31355881 | Novel High-Throughput Quantitation of Potent hERG Blocker Dofetilide in Human Plasma by Liquid Chromatography Tandem Mass Spectrometry: Application in a Phase 1 ECG Biomarker Validation Study. | 2020 Mar 7 |
1 |
| 2 |
32221320 | Cross-site and cross-platform variability of automated patch clamp assessments of drug effects on human cardiac currents in recombinant cells. | 2020 Mar 27 |
1 |
| 3 |
30561737 | Evaluation of Possible Proarrhythmic Potency: Comparison of the Effect of Dofetilide, Cisapride, Sotalol, Terfenadine, and Verapamil on hERG and Native IKr Currents and on Cardiac Action Potential. | 2019 Apr 1 |
1 |
| 4 |
31526813 | Cardiotoxicity screening of illicit drugs and new psychoactive substances (NPS) in human iPSC-derived cardiomyocytes using microelectrode array (MEA) recordings. | 2019 Nov |
1 |
| 5 |
29573040 | F463L increases the potential of dofetilide on human ether-a-go-go-related gene (hERG) channels. | 2018 Jun |
6 |
| 6 |
29940218 | Cross - site comparison of excitation-contraction coupling using impedance and field potential recordings in hiPSC cardiomyocytes. | 2018 Sep - Oct |
1 |
| 7 |
28516454 | A multiscale computational modelling approach predicts mechanisms of female sex risk in the setting of arousal-induced arrhythmias. | 2017 Jul 15 |
1 |
| 8 |
28681507 | Correlation between human ether-a-go-go-related gene channel inhibition and action potential prolongation. | 2017 Sep |
1 |
| 9 |
28868038 | Quantitative Comparison of Effects of Dofetilide, Sotalol, Quinidine, and Verapamil between Human Ex vivo Trabeculae and In silico Ventricular Models Incorporating Inter-Individual Action Potential Variability. | 2017 |
1 |
| 10 |
26777113 | Artificial Neural Network Analysis of Pharmacokinetic and Toxicity Properties of Lead Molecules for Dengue Fever, Tuberculosis and Malaria. | 2016 |
1 |
| 11 |
27731415 | Role of the pH in state-dependent blockade of hERG currents. | 2016 Oct 12 |
1 |
| 12 |
25625756 | Short-term variability in QT interval and ventricular arrhythmias induced by dofetilide are dependent on high-frequency autonomic oscillations. | 2015 Jun |
1 |
| 13 |
26076100 | Inter-study variability of preclinical in vivo safety studies and translational exposure-QTc relationships--a PKPD meta-analysis. | 2015 Sep |
1 |
| 14 |
24200993 | Allosteric modulators of the hERG K(+) channel: radioligand binding assays reveal allosteric characteristics of dofetilide analogs. | 2014 Jan 1 |
1 |
| 15 |
24830940 | Long-term channel block is required to inhibit cellular transformation by human ether-à-go-go-related gene (hERG1) potassium channels. | 2014 Aug |
1 |
| 16 |
23089628 | Repolarization reserve determines drug responses in human pluripotent stem cell derived cardiomyocytes. | 2013 Jan |
1 |
| 17 |
23473309 | Strategies to reduce HERG K+ channel blockade. Exploring heteroaromaticity and rigidity in novel pyridine analogues of dofetilide. | 2013 Apr 11 |
1 |
| 18 |
23518063 | Human embryonic stem cell derived cardiac myocytes detect hERG-mediated repolarization effects, but not Nav1.5 induced depolarization delay. | 2013 Jul-Aug |
1 |
| 19 |
23586323 | Structure-activity relationships of pentamidine-affected ion channel trafficking and dofetilide mediated rescue. | 2013 Jul |
5 |
| 20 |
22609836 | Comparison of the effects of DC031050, a class III antiarrhythmic agent, on hERG channel and three neuronal potassium channels. | 2012 Jun |
1 |
| 21 |
23033485 | Identification and characterization of a compound that protects cardiac tissue from human Ether-à-go-go-related gene (hERG)-related drug-induced arrhythmias. | 2012 Nov 16 |
1 |
| 22 |
21205913 | BeKm-1, a peptide inhibitor of human ether-a-go-go-related gene potassium currents, prolongs QTc intervals in isolated rabbit heart. | 2011 Apr |
2 |
| 23 |
21376840 | Functional characterization of the LQT2-causing mutation R582C and the associated voltage-dependent fluorescence signal. | 2011 Aug |
1 |
| 24 |
21419854 | Pharmacokinetic-pharmacodynamic modelling of the effect of Moxifloxacin on QTc prolongation in telemetered cynomolgus monkeys. | 2011 May-Jun |
1 |
| 25 |
21489024 | Pharmacological inhibition of the hERG potassium channel is modulated by extracellular but not intracellular acidosis. | 2011 Oct |
5 |
| 26 |
20172036 | Investigating dynamic protocol-dependence of hERG potassium channel inhibition at 37 degrees C: Cisapride versus dofetilide. | 2010 Mar-Apr |
2 |
| 27 |
19426697 | Analogs of MK-499 are differentially affected by a mutation in the S6 domain of the hERG K+ channel. | 2009 May 15 |
1 |
| 28 |
19725081 | Exploring chemical substructures essential for HERG k(+) channel blockade by synthesis and biological evaluation of dofetilide analogues. | 2009 Oct |
1 |
| 29 |
18372399 | Probing the binding sites and mechanisms of action of two human ether-a-go-go-related gene channel activators, 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) and 2-[2-(3,4-dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nicotinic acid (PD307243). | 2008 Jun |
1 |
| 30 |
18493243 | Predicting drug-induced changes in QT interval and arrhythmias: QT-shortening drugs point to gaps in the ICHS7B Guidelines. | 2008 Aug |
1 |
| 31 |
18701618 | Drug binding to the inactivated state is necessary but not sufficient for high-affinity binding to human ether-à-go-go-related gene channels. | 2008 Nov |
1 |
| 32 |
17303420 | The synthesis and biological evaluation of novel series of nitrile-containing fluoroquinolones as antibacterial agents. | 2007 Apr 15 |
1 |
| 33 |
17536794 | Fluorescently labeled analogues of dofetilide as high-affinity fluorescence polarization ligands for the human ether-a-go-go-related gene (hERG) channel. | 2007 Jun 28 |
3 |
| 34 |
16474003 | Molecular determinants of HERG channel block. | 2006 May |
1 |
| 35 |
16506891 | Evaluation of the rubidium efflux assay for preclinical identification of HERG blockade. | 2006 Feb |
1 |
| 36 |
15961988 | A pharmacokinetic-pharmacodynamic model for the quantitative prediction of dofetilide clinical QT prolongation from human ether-a-go-go-related gene current inhibition data. | 2005 Jun |
2 |
| 37 |
15519905 | The [3H]dofetilide binding assay is a predictive screening tool for hERG blockade and proarrhythmia: Comparison of intact cell and membrane preparations and effects of altering [K+]o. | 2004 Nov-Dec |
2 |
| 38 |
15522280 | Role of a KCNH2 polymorphism (R1047 L) in dofetilide-induced Torsades de Pointes. | 2004 Nov |
1 |
| 39 |
10804231 | Do glia have heart? Expression and functional role for ether-a-go-go currents in hippocampal astrocytes. | 2000 May 15 |
1 |
| 40 |
11040061 | Pharmacological blockade of ERG K(+) channels and Ca(2+) influx through store-operated channels exerts opposite effects on intracellular Ca(2+) oscillations in pituitary GH(3) cells. | 2000 Nov |
1 |