Oligonucleotides

transforming growth factor alpha ; Homo sapiens







26 Article(s)
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Pub. Year
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1 35057094 Safe and Effective Cynomolgus Monkey GLP-Tox Study with Repetitive Intrathecal Application of a TGFBR2 Targeting LNA-Gapmer Antisense Oligonucleotide as Treatment Candidate for Neurodegenerative Disorders. 2022 Jan 15 1
2 35454784 Differences in the Expression Patterns of TGFβ Isoforms and Associated Genes in Astrocytic Brain Tumors. 2022 Apr 8 1
3 33823905 Novel therapies emerging in oncology to target the TGF-β pathway. 2021 Apr 6 1
4 34560077 TGF-β-induced fibrosis: A review on the underlying mechanism and potential therapeutic strategies. 2021 Nov 15 1
5 32178467 Antisense Oligonucleotide in LNA-Gapmer Design Targeting TGFBR2-A Key Single Gene Target for Safe and Effective Inhibition of TGFβ Signaling. 2020 Mar 12 1
6 32179111 Lung-targeted delivery of TGF-β antisense oligonucleotides to treat pulmonary fibrosis. 2020 Jun 10 2
7 32194176 TGF-β activity restoration and phosphodiesterase 4 inhibition as therapeutic options for inflammatory bowel diseases. 2020 May 1
8 32710930 Clinical development of therapies targeting TGFβ: current knowledge and future perspectives. 2020 Oct 1
9 17972023 Treatment of MCF-7 breast cancer cells employing mono- and bispecific antisense oligonucleotides having binding specificity toward proteins associated with autocrine regulated growth and BCL-2. 2008 2
10 17848743 Bispecific antisense oligonucleotides having binding sites directed against an autocrine regulated growth pathway and bcl-2 for the treatment of prostate tumors. 2007 2
11 17917084 Combination chemotherapy employing bispecific antisense oligonucleotides having binding sites directed against an autocrine regulated growth pathway and bcl-2 for the treatment of prostate tumors. 2007 1
12 16870352 Synthesis of branched antisense oligonucleotides having multiple specificities. Treatment of hormone insensitive prostate cancer. 2006 2
13 17136230 Bispecific antisense oligonucleotides with multiple binding sites for the treatment of prostate tumors and their applicability to combination therapy. 2006 Oct 2
14 12665682 Inhibition of PC-3 prostate cancer cell growth in vitro using both antisense oligonucleotides and taxol. 2003 2
15 12616956 Backbone modification alters the efficacy of antisense oligonucleotides directed against mRNA encoding either TGF-alpha or EGFR in the treatment of prostate cancer cell lines. 2002 Dec 2
16 11778757 Treatment of the T98G glioblastoma cell line with antisense oligonucleotides directed toward mRNA encoding transforming growth factor-alpha and the epidermal growth factor receptor. 2001 2
17 11127817 Simultaneous blockage of different EGF-like growth factors results in efficient growth inhibition of human colon carcinoma xenografts. 2000 Nov 30 1
18 10370022 Increased expression of transforming growth factor-alpha in infantile hypertrophic pyloric stenosis. 1999 1
19 9466051 Epidermal growth factor-related peptides as targets for experimental therapy of human colon carcinoma. 1998 1
20 9513046 Downmodulation of TGF-alpha protein expression with antisense oligonucleotides inhibits proliferation of head and neck squamous carcinoma but not normal mucosal epithelial cells. 1998 Apr 1 4
21 9232607 Enhanced expression of bcl-2 following antisense oligonucleotide mediated growth factor deprivation. 1997 Mar 1
22 7593635 Activation of hepatic stellate cells by TGF alpha and collagen type I is mediated by oxidative stress through c-myb expression. 1995 Nov 1
23 8360485 IL-8 produced by human malignant melanoma cells in vitro is an essential autocrine growth factor. 1993 Sep 1 1
24 1457828 Anti-sense transforming growth factor alpha oligonucleotides inhibit autocrine stimulated proliferation of a colon carcinoma cell line. 1992 Nov 5
25 2009597 Molecular cloning of the complementary DNA encoding for the hamster TGF-alpha mature peptide. 1991 Mar 1
26 2072905 The proliferative and morphologic responses of a colon carcinoma cell line (LIM 1215) require the production of two autocrine factors. 1991 Aug 3