| 1 |
35470784 | Effect of pH on structural dynamics of HMG-CoA reductase and binding affinity to β-sitosterol. | 2022 Apr 26 |
2 |
| 2 |
33307558 | Role of the Mevalonate Pathway in Adrenocortical Tumorigenesis. | 2021 Feb |
3 |
| 3 |
33109681 | Depletion of essential isoprenoids and ER stress induction following acute liver-specific deletion of HMG-CoA reductase. | 2020 Dec |
1 |
| 4 |
29107682 | Underlying mechanisms for sterol-induced ubiquitination and ER-associated degradation of HMG CoA reductase. | 2018 Sep |
1 |
| 5 |
29935271 | Modulation of heat shock proteins by statins. | 2018 Aug |
2 |
| 6 |
29077483 | Risk of Late-Onset Alzheimer's Disease by Plasma Cholesterol: Rational In Silico Drug Investigation of Pyrrole-Based HMG-CoA Reductase Inhibitors. | 2017 Oct/Nov |
2 |
| 7 |
25742604 | The prenyltransferase UBIAD1 is the target of geranylgeraniol in degradation of HMG CoA reductase. | 2015 Mar 5 |
1 |
| 8 |
26181205 | Intracellular oxygen determined by respiration regulates localization of Ras and prenylated proteins. | 2015 Jul 16 |
2 |
| 9 |
26425463 | Pleiotropic effects of statins. | 2015 Sep-Oct |
1 |
| 10 |
24582968 | Targeting the mevalonate cascade as a new therapeutic approach in heart disease, cancer and pulmonary disease. | 2014 Jul |
2 |
| 11 |
24587072 | Increased actin polymerization and stabilization interferes with neuronal function and survival in the AMPKγ mutant Loechrig. | 2014 |
1 |
| 12 |
24732207 | Developmental processes regulated by the 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) pathway: highlights from animal studies. | 2014 Jul |
2 |
| 13 |
24025715 | Sterol-induced dislocation of 3-hydroxy-3-methylglutaryl coenzyme A reductase from membranes of permeabilized cells. | 2013 Nov |
1 |
| 14 |
24386216 | Exploration of virtual candidates for human HMG-CoA reductase inhibitors using pharmacophore modeling and molecular dynamics simulations. | 2013 |
1 |
| 15 |
21789486 | The analytical determination of isoprenoid intermediates from the mevalonate pathway. | 2012 Jan |
1 |
| 16 |
22177940 | Explication of interactions between HMGCR isoform 2 and various statins through In silico modeling and docking. | 2012 Feb |
2 |
| 17 |
22722993 | Bioinformatics study of the 3-hydroxy-3-methylglotaryl-coenzyme A reductase (HMGR) gene in Gramineae. | 2012 Sep |
2 |
| 18 |
21586555 | Effects of farnesyl pyrophosphate accumulation on calvarial osteoblast differentiation. | 2011 Aug |
5 |
| 19 |
21701259 | Modulation of plant HMG-CoA reductase by protein phosphatase 2A: positive and negative control at a key node of metabolism. | 2011 Aug |
2 |
| 20 |
21903868 | A novel bisphosphonate inhibitor of squalene synthase combined with a statin or a nitrogenous bisphosphonate in vitro. | 2011 Nov |
1 |
| 21 |
20696928 | Dysregulation of the mevalonate pathway promotes transformation. | 2010 Aug 24 |
2 |
| 22 |
21435278 | [Muscle problems due to statins: underestimated]. | 2010 |
1 |
| 23 |
19075102 | Evidence for statin pleiotropy in humans: differential effects of statins and ezetimibe on rho-associated coiled-coil containing protein kinase activity, endothelial function, and inflammation. | 2009 Jan 6 |
1 |
| 24 |
19814665 | Statin use before and after acute ischemic stroke onset improves neurological outcome. | 2009 Oct |
1 |
| 25 |
19856009 | Quantitative determination of geranyl diphosphate levels in cultured human cells. | 2009 Nov |
1 |
| 26 |
17666454 | Geranylgeranyl pyrophosphate stimulates gamma-secretase to increase the generation of Abeta and APP-CTFgamma. | 2008 Jan |
1 |
| 27 |
18625202 | HMG-CoA reductase inhibitor simvastatin overcomes bortezomib-induced apoptosis resistance by disrupting a geranylgeranyl pyrophosphate-dependent survival pathway. | 2008 Sep 19 |
1 |
| 28 |
17322126 | Asbestos induces nitric oxide synthesis in mesothelioma cells via Rho signaling inhibition. | 2007 Jun |
1 |
| 29 |
17601486 | Perillyl alcohol and genistein differentially regulate PKB/Akt and 4E-BP1 phosphorylation as well as eIF4E/eIF4G interactions in human tumor cells. | 2007 Sep 1 |
1 |
| 30 |
18078012 | Are pleiotropic effects of statins real? | 2007 |
1 |
| 31 |
16476765 | Isoprenoids determine Th1/Th2 fate in pathogenic T cells, providing a mechanism of modulation of autoimmunity by atorvastatin. | 2006 Feb 20 |
1 |
| 32 |
16774905 | HMG-CoA reductase inhibitor simvastatin mitigates VEGF-induced "inside-out" signaling to extracellular matrix by preventing RhoA activation. | 2006 Nov |
1 |
| 33 |
16007821 | Pleiotropic effects of statins in atherosclerosis: role on endothelial function, inflammation and immunomodulation. | 2005 Jun |
1 |
| 34 |
15019531 | Fluvastatin inhibits raft dependent Fcgamma receptor signalling in human monocytes. | 2004 Feb |
1 |
| 35 |
15861311 | Statins effect on smooth muscle cell proliferation. | 2004 Nov |
1 |
| 36 |
12477733 | Regulation of isoprenoid/cholesterol biosynthesis in cells from mevalonate kinase-deficient patients. | 2003 Feb 21 |
1 |
| 37 |
12514264 | Plant-derived monoterpenes suppress hamster kidney cell 3-hydroxy-3-methylglutaryl coenzyme a reductase synthesis at the post-transcriptional level. | 2003 Jan |
5 |
| 38 |
12454262 | A second gene for peroxisomal HMG-CoA reductase? A genomic reassessment. | 2002 Dec |
2 |
| 39 |
15989499 | The effect of HMG-CoA reductase inhibitors on chronic allograft rejection. | 2001 Apr |
1 |
| 40 |
10698924 | Crystal structure of the catalytic portion of human HMG-CoA reductase: insights into regulation of activity and catalysis. | 2000 Mar 1 |
2 |
| 41 |
9927296 | Prenyltransferase inhibitors induce apoptosis in proliferating thyroid cells through a p53-independent CrmA-sensitive, and caspase-3-like protease-dependent mechanism. | 1999 Feb |
1 |
| 42 |
10460692 | Isoprenoid-mediated inhibition of mevalonate synthesis: potential application to cancer. | 1999 Sep |
2 |
| 43 |
10665838 | New insights into the pharmacodynamic and pharmacokinetic properties of statins. | 1999 Dec |
1 |
| 44 |
8626470 | Regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase degradation by the nonsterol mevalonate metabolite farnesol in vivo. | 1996 Apr 5 |
1 |
| 45 |
7782923 | Suppression of mevalonate pathway activities by dietary isoprenoids: protective roles in cancer and cardiovascular disease. | 1995 Jun |
1 |
| 46 |
8562480 | Reversion of transformed phenotype of human adenocarcinoma A549 cells by expression of 3-hydroxy-3-methylglutaryl coenzyme A reductase complementary DNA. | 1995 Nov |
1 |
| 47 |
7964176 | Regulation of HMG-CoA reductase activity in plants. | 1994 Jul |
1 |
| 48 |
8158898 | Cholesterol synthesis inhibitors inhibit more than cholesterol synthesis. | 1994 Feb |
1 |
| 49 |
1314600 | The localization, partial purification and regulation of pea plastid HMG-CoA reductase. | 1992 Apr 15 |
1 |
| 50 |
1358611 | Evidence for a protein kinase cascade in higher plants. 3-Hydroxy-3-methylglutaryl-CoA reductase kinase. | 1992 Nov 1 |
2 |