2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one

matrix metallopeptidase 2 ; Homo sapiens







51 Article(s)
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1 33997938 Curcumin Inhibits Viability of Clear Cell Renal Cell Carcinoma by Down-Regulating ADAMTS18 Gene Methylation though NF-κ B and AKT Signaling Pathway. 2022 May 1
2 33411234 Impaired capillary tube formation induced by elevated secretion of IL8 involves altered signaling via the CXCR1/PI3K/MMP2 pathway. 2021 Jan 1
3 34076985 Baicalein inhibits invasion and promotes apoptosis in glioma cells through the PI3K/Akt pathway. 2021 Mar-Apr 1
4 30282494 Knockdown of activated Cdc42-associated kinase inhibits human extravillous trophoblast migration and invasion and decreases protein expression of pho-Akt and matrix metalloproteinase. 2020 Apr 1
5 32825931 Rab11a regulates MMP2 expression by activating the PI3K/AKT pathway in human hepatocellular carcinoma cells. 2020 Sep 1
6 30074136 Epidermal growth factor receptor-mediated regulation of matrix metalloproteinase-2 and matrix metalloproteinase-9 in MCF-7 breast cancer cells. 2019 Feb 1
7 30353649 IL-17A promotes cell migration and invasion of glioblastoma cells via activation of PI3K/AKT signalling pathway. 2019 Jan 1
8 30668826 miR-188-5p regulates proliferation and invasion via PI3K/Akt/MMP-2/9 signaling in keloids. 2019 Feb 1 1
9 31026389 Praeruptorin-B Inhibits 12-O-Tetradecanoylphorbol-13-Acetate-Induced Cell Invasion by Targeting AKT/NF-κB via Matrix Metalloproteinase-2/-9 Expression in Human Cervical Cancer Cells. 2019 1
10 29137974 Effects and mechanisms of matrix metalloproteinase2 on neural differentiation of induced pluripotent stem cells. 2018 Jan 1 1
11 29805303 Elongator promotes the migration and invasion of hepatocellular carcinoma cell by the phosphorylation of AKT. 2018 1
12 30225216 Effects of LY294002 on the function of retinal endothelial cell in vitro. 2018 2
13 28844616 MicroRNA-21 promotes bone mesenchymal stem cells migration in vitro by activating PI3K/Akt/MMPs pathway. 2017 Dec 1
14 31966870 CXCR4 enhances invasion and proliferation of bone marrow stem cells via PI3K/AKT/NF-κB signaling pathway. 2017 1
15 26639237 The effect of PI3K inhibitor LY294002 and gemcitabine hydrochloride combined with ionizing radiation on the formation of vasculogenic mimicry of Panc-1 cells in vitro and in vivo. 2016 2
16 26814361 CTRP9 Ameliorates Pulmonary Arterial Hypertension Through Attenuating Inflammation and Improving Endothelial Cell Survival and Function. 2016 May 1
17 27035160 Salinomycin causes migration and invasion of human fibrosarcoma cells by inducing MMP-2 expression via PI3-kinase, ERK-1/2 and p38 kinase pathways. 2016 Jun 1
18 27098148 IL-17A Promotes the Migration and Invasiveness of Colorectal Cancer Cells Through NF-κB-Mediated MMP Expression. 2016 1
19 27176045 Slit2 and Robo1 induce opposing effects on metastasis of hepatocellular carcinoma Sk-hep-1 cells. 2016 Jul 1
20 27206970 Testosterone delays vascular smooth muscle cell senescence and inhibits collagen synthesis via the Gas6/Axl signaling pathway. 2016 Jun 1
21 25378227 Twist-related protein 1 enhances oral tongue squamous cell carcinoma cell invasion through β-catenin signaling. 2015 Mar 1
22 25712031 Mechanical stretch promotes matrix metalloproteinase-2 and prolyl-4-hydroxylase α1 production in human aortic smooth muscle cells via Akt-p38 MAPK-JNK signaling. 2015 May 1
23 26062523 IRX2-mediated upregulation of MMP-9 and VEGF in a PI3K/AKT-dependent manner. 2015 Sep 1
24 26299938 Activation of sonic hedgehog signaling enhances cell migration and invasion by induction of matrix metalloproteinase-2 and -9 via the phosphoinositide-3 kinase/AKT signaling pathway in glioblastoma. 2015 Nov 1
25 26513500 IGF-1 Regulates the Extracellular Level of Active MMP-2 and Promotes Müller Glial Cell Motility. 2015 Oct 1
26 24176823 Roles for GP IIb/IIIa and αvβ3 integrins in MDA-MB-231 cell invasion and shear flow-induced cancer cell mechanotransduction. 2014 Mar 1 1
27 24700142 SOX2 promotes the migration and invasion of laryngeal cancer cells by induction of MMP-2 via the PI3K/Akt/mTOR pathway. 2014 Jun 1
28 24816639 Knockdown of sphingosine kinase 1 inhibits the migration and invasion of human rheumatoid arthritis fibroblast-like synoviocytes by down-regulating the PI3K/AKT activation and MMP-2/9 production in vitro. 2014 Aug 2
29 23461061 C-Myc overexpression promotes osteosarcoma cell invasion via activation of MEK-ERK pathway. 2012 1
30 21276823 Downregulation of Akt and FAK phosphorylation reduces invasion of glioblastoma cells by impairment of MT1-MMP shuttling to lamellipodia and downregulates MMPs expression. 2011 May 1
31 19956873 Environmental endocrine disruptors promote invasion and metastasis of SK-N-SH human neuroblastoma cells. 2010 Jan 1
32 20428814 PTEN inhibits the migration and invasion of HepG2 cells by coordinately decreasing MMP expression via the PI3K/Akt pathway. 2010 Jun 1
33 20607860 Cisplatin and PI3kinase inhibition decrease invasion and migration of human ovarian carcinoma cells and regulate matrix-metalloproteinase expression. 2010 Aug 1
34 20698845 Transforming growth factor-β enhances matrix metalloproteinase-2 expression and activity through AKT in fibroblasts derived from angiofibromas in patients with tuberous sclerosis complex. 2010 Dec 1
35 21126656 Possible mechanism of betel-quid-extract-induced expression of matrix metalloproteinase-2. 2010 Nov 1
36 19338750 Angiotensin II induces MMP 2 activity via FAK/JNK pathway in human endothelial cells. 2009 Mar 20 1
37 19859997 Effects of LY294002 on the invasiveness of human gastric cancer in vivo in nude mice. 2009 Oct 28 1
38 18707587 Implication of alpha5beta1 integrin in invasion of drug-resistant MCF-7/ADR breast carcinoma cells: a role for MMP-2 collagenase. 2008 Jul 1
39 18805481 4-Hydroxynonenal enhances MMP-2 production in vascular smooth muscle cells via mitochondrial ROS-mediated activation of the Akt/NF-kappaB signaling pathways. 2008 Nov 15 1
40 16722795 EGF-induced cell migration is mediated by ERK and PI3K/AKT pathways in cultured human lens epithelial cells. 2006 Apr 2
41 17018612 Absence of CD9 enhances adhesion-dependent morphologic differentiation, survival, and matrix metalloproteinase-2 production in small cell lung cancer cells. 2006 Oct 1 1
42 17046572 Chemotherapy disrupts activity of translational regulatory proteins in bone marrow stromal cells. 2006 Nov 1
43 17341207 Culture of human fibrosarcoma HT-1080 cells in presence of fibronectin activates MMP-2. 2006 2
44 16241951 Intraplatelet signaling mechanisms of the priming effect of matrix metalloproteinase-2 on platelet aggregation. 2005 Nov 2
45 16411407 Homocysteine rapidly increases matrix metalloproteinase-2 expression and activity in cultured human vascular smooth muscle cells. Role of phosphatidyl inositol 3-kinase and mitogen activated protein kinase pathways. 2005 Dec 1
46 15102045 Examination of the signal transduction pathways leading to activation of gelatinolytic activity by interleukin-1alpha and Porphyromonas gingivalis in human osteosarcoma cells. 2004 Jun 1
47 15220345 Group IB secretory phospholipase A2 promotes matrix metalloproteinase-2-mediated cell migration via the phosphatidylinositol 3-kinase and Akt pathway. 2004 Aug 27 1
48 15297252 Activation of MMP-2 in response to vascular injury is mediated by phosphatidylinositol 3-kinase-dependent expression of MT1-MMP. 2004 Dec 1
49 12697668 Androgen stimulates matrix metalloproteinase-2 expression in human prostate cancer. 2003 May 1
50 12805379 K-ras regulates the steady-state expression of matrix metalloproteinase 2 in fibroblasts. 2003 Aug 22 1