TEPP-46

pyruvate kinase, muscle ; Mus musculus







12 Article(s)
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1 33314682 The PKM2 activator TEPP-46 suppresses kidney fibrosis via inhibition of the EMT program and aberrant glycolysis associated with suppression of HIF-1α accumulation. 2021 May 2
2 34156680 The PKM2 activator TEPP-46 attenuates MCD feeding-induced nonalcoholic steatohepatitis by inhibiting the activation of Kupffer cells. 2021 Jun 6
3 34798593 Pyruvate kinase M2 (PKM2) interacts with activating transcription factor 2 (ATF2) to bridge glycolysis and pyroptosis in microglia. 2021 Dec 1
4 32198052 Nuclear accumulation of pyruvate kinase M2 promotes liver regeneration via activation of signal transducer and activator of transcription 3. 2020 Jun 1 1
5 32323562 PKM2 Activator TEPP-46 Attenuates Thoracic Aortic Aneurysm and Dissection by Inhibiting NLRP3 Inflammasome-Mediated IL-1β Secretion. 2020 Jul 2
6 32719938 Pyruvate kinase M2 activation protects against the proliferation and migration of pulmonary artery smooth muscle cells. 2020 Dec 1
7 33061637 Oxymatrine Inhibits Colorectal Cancer Metastasis via Attenuating PKM2-Mediated Aerobic Glycolysis. 2020 2
8 33131100 Sirtuin 3 governs autophagy-dependent glycolysis during Angiotensin II-induced endothelial-to-mesenchymal transition. 2020 Dec 1
9 33542713 Activator-Mediated Pyruvate Kinase M2 Activation Contributes to Endotoxin Tolerance by Promoting Mitochondrial Biogenesis. 2020 4
10 29552018 Caloric Restriction Mimetic 2-Deoxyglucose Alleviated Inflammatory Lung Injury via Suppressing Nuclear Pyruvate Kinase M2-Signal Transducer and Activator of Transcription 3 Pathway. 2018 1
11 28436957 Pyruvate kinase M2 activation may protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction. 2017 Jun 2
12 23905203 ML265: A potent PKM2 activator induces tetramerization and reduces tumor formation and size in a mouse xenograft model 2010 2