| Protein Name | lysyl-tRNA synthetase 1 |
|---|---|
| Organism | Rattus norvegicus |
| Gene ID | 292028 |
| Gene Symbol | Kars1 |
| UniProt | Q5XIM7 (SYK_RAT) |
| Relationships |
Total Number of functionally related compound(s) :
18
Total Number of Articles : 16 |
Description |
lysyl-tRNA synthetase 1 |
| Gene Summary |
Enables several functions, including ATP binding activity; lysine-tRNA ligase activity; and tRNA binding activity. Involved in several processes, including ERK1 and ERK2 cascade; diadenosine tetraphosphate biosynthetic process; and lysyl-tRNA aminoacylation. Located in cytoplasm and nucleus. Part of aminoacyl-tRNA synthetase multienzyme complex. Biomarker of sciatic neuropathy. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease recessive intermediate B and autosomal recessive nonsyndromic deafness 89. Orthologous to human KARS1 (lysyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Jun 2025] |
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| Properties | |