| Protein Name | diphthamide biosynthesis 3 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 285381 |
| Gene Symbol | DPH3 |
| UniProt | Q96FX2 (DPH3_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
11
Total Number of Articles : 7 |
Description |
diphthamide biosynthesis 3 |
| Gene Summary |
This gene encodes a CSL zinc finger-containing protein that is required for dipthamide biosynthesis. The encoded protein is necessary for the initial step in the modification of a histidine residue in elongation factor-2 to diphthamide. This modified residue is a target for ADP ribosylation by the bacterial toxins diphtheria toxin and Pseudomonas exotoxin A. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Feb 2009] |
| synonyms |
|
| Properties | |