| Protein Name | Dopamine transporter |
|---|---|
| Organism | Drosophila melanogaster |
| Gene ID | 36849 |
| Gene Symbol | DAT |
| UniProt | Q7K4Y6 (DAT_DROME), A0A0B4KEX2 (A0A0B4KEX2_DROME) |
| Relationships |
Total Number of functionally related compound(s) :
92
Total Number of Articles : 79 |
Description |
Dopamine transporter |
| Gene Summary |
Enables cocaine binding activity and dopamine:sodium symporter activity. Involved in several processes, including dopamine transport; regulation of presynaptic cytosolic calcium ion concentration; and response to odorant. Located in plasma membrane. Is expressed in several structures, including anlage in statu nascendi; anterior-posterior subdivision of organism; dopaminergic neurons; mushroom body slice; and synaptic neuropil domain. Used to study attention deficit hyperactivity disorder; autism spectrum disorder; and classic dopamine transporter deficiency syndrome. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; attention deficit hyperactivity disorder; classic dopamine transporter deficiency syndrome; mild cognitive impairment; and neurocirculatory asthenia. Orthologous to human SLC6A2 (solute carrier family 6 member 2) and SLC6A3 (solute carrier family 6 member 3). [provided by Alliance of Genome Resources, Jul 2025] |
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| Properties | |