| Protein Name | interleukin 6 cytokine family signal transducer |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 3572 |
| Gene Symbol | IL6ST |
| UniProt | P40189 (IL6RB_HUMAN), Q17RA0 (Q17RA0_HUMAN), A0A0A0N0L2 (A0A0A0N0L2_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
154
Total Number of Articles : 241 |
Description |
interleukin 6 cytokine family signal transducer |
| Gene Summary |
The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, May 2014] |
| synonyms |
|
| Properties | |