Protein Name interleukin 6 cytokine family signal transducer
Organism Homo sapiens
Gene ID 3572
Gene Symbol

IL6ST

UniProt P40189 (IL6RB_HUMAN), Q17RA0 (Q17RA0_HUMAN), A0A0A0N0L2 (A0A0A0N0L2_HUMAN)
Relationships Total Number of functionally related compound(s) : 154
Total Number of Articles : 241
Description

interleukin 6 cytokine family signal transducer

Gene Summary

The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, May 2014]

synonyms
  • interleukin-6 receptor subunit beta
  • CD130 antigen
  • IL-6 receptor subunit beta
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Properties