Protein Name RUNX1 partner transcriptional co-repressor 1
Organism Homo sapiens
Gene ID 862
Gene Symbol


UniProt Q06455 (MTG8_HUMAN), A0A087WWT6 (A0A087WWT6_HUMAN), W8FW32 (W8FW32_HUMAN), B2R6I9 (B2R6I9_HUMAN), A0A0A0MSU1 (A0A0A0MSU1_HUMAN)
Relationships Total Number of functionally related compound(s) : 225
Total Number of Articles : 192

RUNX1 partner transcriptional co-repressor 1

Gene Summary

This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]

  • protein CBFA2T1
  • RUNX1 translocation partner 1
  • acute myelogenous leukemia 1 translocation 1, cyclin-D related
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