| Protein Name | mesencephalic astrocyte derived neurotrophic factor |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 7873 |
| Gene Symbol | MANF |
| UniProt | P55145 (MANF_HUMAN), A8K878 (A8K878_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
146
Total Number of Articles : 91 |
Description |
mesencephalic astrocyte derived neurotrophic factor |
| Gene Summary |
The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphisms in the N-terminal arginine-rich region, including a specific mutation that changes an ATG start codon to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus no longer thought to be tumor-related. [provided by RefSeq, Apr 2014] |
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| Properties | |