| Protein Name | leucyl-tRNA synthetase 1 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 51520 |
| Gene Symbol | LARS1 |
| UniProt | Q9P2J5 (SYLC_HUMAN), B4DER1 (B4DER1_HUMAN), A0A6I8PL42 (A0A6I8PL42_HUMAN), B4E266 (B4E266_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
52
Total Number of Articles : 59 |
Description |
leucyl-tRNA synthetase 1 |
| Gene Summary |
This gene encodes a cytosolic leucine-tRNA synthetase, a member of the class I aminoacyl-tRNA synthetase family. The encoded enzyme catalyzes the ATP-dependent ligation of L-leucine to tRNA(Leu). It is found in the cytoplasm as part of a multisynthetase complex and interacts with the arginine tRNA synthetase through its C-terminal domain. A mutation in this gene was found in affected individuals with infantile liver failure syndrome 1. Alternatively spliced transcript variants of this gene have been observed. [provided by RefSeq, Dec 2015] |
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| Properties | |