| Protein Name | legumain |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 5641 |
| Gene Symbol | LGMN |
| UniProt | Q99538 (LGMN_HUMAN), Q53XC6 (Q53XC6_HUMAN), Q96CY7 (Q96CY7_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
79
Total Number of Articles : 56 |
Description |
legumain |
| Gene Summary |
This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform. [provided by RefSeq, Jul 2008] |
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| Properties | |