Protein Name ubiquitin protein ligase E3 component n-recognin 5
Organism Homo sapiens
Gene ID 51366
Gene Symbol

UBR5

UniProt O95071 (UBR5_HUMAN)
Relationships Total Number of functionally related compound(s) : 51
Total Number of Articles : 41
Description

ubiquitin protein ligase E3 component n-recognin 5

Gene Summary

This gene encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation. [provided by RefSeq, Jul 2008]

synonyms
  • E3 ubiquitin-protein ligase UBR5
  • E3 identified by differential display
  • E3 ubiquitin-protein ligase, HECT domain-containing 1
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Properties