| Protein Name | aldo-keto reductase family 1 member C1 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 1645 |
| Gene Symbol | AKR1C1 |
| UniProt | Q04828 (AK1C1_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
261
Total Number of Articles : 178 |
Description |
aldo-keto reductase family 1 member C1 |
| Gene Summary |
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq, Jul 2008] |
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