| Protein Name | ubiquitin conjugating enzyme E2 K |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 3093 |
| Gene Symbol | UBE2K |
| UniProt | P61086 (UBE2K_HUMAN), B3KSH4 (B3KSH4_HUMAN), B4DIZ2 (B4DIZ2_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
115
Total Number of Articles : 74 |
Description |
ubiquitin conjugating enzyme E2 K |
| Gene Summary |
The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. This protein interacts with RING finger proteins, and it can ubiquitinate huntingtin, the gene product for Huntington's disease. Known functions for this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains from the endoplasmic reticulum, and involvement in foam cell formation. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] |
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