Protein Name 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
Organism Homo sapiens
Gene ID 4552
Gene Symbol


Relationships Total Number of functionally related compound(s) : 130
Total Number of Articles : 269

5-methyltetrahydrofolate-homocysteine methyltransferase reductase

Gene Summary

This gene encodes a member of the ferredoxin-NADP(+) reductase (FNR) family of electron transferases. This protein functions in the synthesis of methionine by regenerating methionine synthase to a functional state. Because methionine synthesis requires methyl-group transfer by a folate donor, activity of the encoded enzyme is important for folate metabolism and cellular methylation. Mutations in this gene can cause homocystinuria-megaloblastic anemia, cbl E type. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]

  • methionine synthase reductase
  • [methionine synthase]-cobalamin methyltransferase (cob(II)alamin reducing)
  • aqCbl reductase
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