| Protein Name | histidyl-tRNA synthetase 1 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 3035 |
| Gene Symbol | HARS1 |
| UniProt | P12081 (HARS1_HUMAN), B4E1C5 (B4E1C5_HUMAN), B4DDD8 (B4DDD8_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
22
Total Number of Articles : 20 |
Description |
histidyl-tRNA synthetase 1 |
| Gene Summary |
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a cytoplasmic enzyme which belongs to the class II family of aminoacyl-tRNA synthetases. The enzyme is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins. The gene is located in a head-to-head orientation with HARSL on chromosome five, where the homologous genes share a bidirectional promoter. The gene product is a frequent target of autoantibodies in the human autoimmune disease polymyositis/dermatomyositis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012] |
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