Protein Name heparanase
Organism Homo sapiens
Gene ID 10855
Gene Symbol

HPSE

UniProt Q9Y251 (HPSE_HUMAN)
Relationships Total Number of functionally related compound(s) : 154
Total Number of Articles : 311
Description

heparanase

Gene Summary

Heparan sulfate proteoglycans are major components of the basement membrane and extracellular matrix. The protein encoded by this gene is an enzyme that cleaves heparan sulfate proteoglycans to permit cell movement through remodeling of the extracellular matrix. In addition, this cleavage can release bioactive molecules from the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

synonyms
  • heparanase
  • endo-glucoronidase
  • heparanase-1
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Properties