Protein Name thiopurine methyltransferase
Organism Mus musculus
Gene ID 22017
Gene Symbol

Tpmt

UniProt O55060 (TPMT_MOUSE), A0A0R4J018 (A0A0R4J018_MOUSE)
Relationships Total Number of functionally related compound(s) : 16
Total Number of Articles : 15
Description

thiopurine methyltransferase

Gene Summary

Enables thiopurine S-methyltransferase activity. Predicted to be involved in xenobiotic metabolic process. Predicted to be located in cytoplasm. Is expressed in metanephros. Used to study poor metabolism of thiopurines. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; alopecia; leukopenia; and poor metabolism of thiopurines 1. Orthologous to human TPMT (thiopurine S-methyltransferase). [provided by Alliance of Genome Resources, Jul 2025]

synonyms
  • thiopurine S-methyltransferase
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Properties