| Protein Name | selenoprotein F |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 9403 |
| Gene Symbol | SELENOF |
| UniProt | O60613 (SEP15_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
17
Total Number of Articles : 25 |
Description |
selenoprotein F |
| Gene Summary |
The protein encoded by this gene belongs to the SEP15/selenoprotein M family. The exact function of this protein is not known; however, it has been found to associate with UDP-glucose:glycoprotein glucosyltransferase (UGTR), an endoplasmic reticulum(ER)-resident protein, which is involved in the quality control of protein folding. The association with UGTR retains this protein in the ER, where it may play a role in protein folding. It has also been suggested to have a role in cancer etiology. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2016] |
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