| Protein Name | coagulation factor III, tissue factor |
|---|---|
| Organism | Mus musculus |
| Gene ID | 14066 |
| Gene Symbol | F3 |
| UniProt | P20352 (TF_MOUSE), A0A0R4J088 (A0A0R4J088_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
197
Total Number of Articles : 163 |
Description |
coagulation factor III, tissue factor |
| Gene Summary |
This gene encodes a membrane-bound glycoprotein that forms the primary physiological initiator of the blood coagulation process following vascular damage. The encoded protein binds to coagulation factor VIIa and the ensuing complex catalyzes the proteolytic activation of coagulation factors IX and X. Mice lacking encoded protein die in utero resulting from massive hemorrhaging in both extraembryonic and embryonic vessels. A severe deficiency of the encoded protein in mice results in impaired uterine homeostasis, shorter life spans due to spontaneous fatal hemorrhages and cardiac fibrosis. [provided by RefSeq, Aug 2015] |
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