Protein Name neurofilament medium chain
Organism Rattus norvegicus
Gene ID 24588
Gene Symbol

Nefm

UniProt P12839 (NFM_RAT)
Relationships Total Number of functionally related compound(s) : 49
Total Number of Articles : 37
Description

neurofilament medium chain

Gene Summary

Enables signaling receptor binding activity and toxic substance binding activity. Involved in several processes, including cellular response to estradiol stimulus; intermediate filament cytoskeleton organization; and nervous system development. Located in axon; neurofilament; and perikaryon. Used to study amyotrophic lateral sclerosis and congenital hypothyroidism. Biomarker of hypothyroidism; sciatic neuropathy; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in Alzheimer's disease and human immunodeficiency virus infectious disease. Orthologous to human NEFM (neurofilament medium chain). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • neurofilament medium polypeptide
  • 160 kDa neurofilament protein
  • NF-M
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Properties