| Protein Name | adhesion G protein-coupled receptor L1 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 22859 |
| Gene Symbol | ADGRL1 |
| UniProt | O94910 (AGRL1_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
123
Total Number of Articles : 100 |
Description |
adhesion G protein-coupled receptor L1 |
| Gene Summary |
This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Oct 2008] |
| synonyms |
|
| Properties | |