Protein Name N-acetylneuraminate pyruvate lyase
Organism Homo sapiens
Gene ID 80896
Gene Symbol

NPL

UniProt Q9BXD5 (NPL_HUMAN), A0A087WZ70 (A0A087WZ70_HUMAN)
Relationships Total Number of functionally related compound(s) : 123
Total Number of Articles : 83
Description

N-acetylneuraminate pyruvate lyase

Gene Summary

This gene encodes a member of the N-acetylneuraminate lyase sub-family of (beta/alpha)(8)-barrel enzymes. N-acetylneuraminate lyases regulate cellular concentrations of N-acetyl-neuraminic acid (sialic acid) by mediating the reversible conversion of sialic acid into N-acetylmannosamine and pyruvate. A pseudogene of this gene is located on the short arm of chromosome 2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

synonyms
  • N-acetylneuraminate lyase
  • N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
  • N-acetylneuraminic acid aldolase
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Properties