| Protein Name | cytokine inducible SH2 containing protein |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 1154 |
| Gene Symbol | CISH |
| UniProt | Q9NSE2 (CISH_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
217
Total Number of Articles : 154 |
Description |
cytokine inducible SH2 containing protein |
| Gene Summary |
The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008] |
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