| Protein Name | NADH:ubiquinone oxidoreductase core subunit S7 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 374291 |
| Gene Symbol | NDUFS7 |
| UniProt | O75251 (NDUS7_HUMAN), Q7LD69 (Q7LD69_HUMAN), Q6ZS38 (Q6ZS38_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
23
Total Number of Articles : 22 |
Description |
NADH:ubiquinone oxidoreductase core subunit S7 |
| Gene Summary |
This gene encodes a protein that is a subunit of one of the complexes that forms the mitochondrial respiratory chain. This protein is one of over 40 subunits found in complex I, the nicotinamide adenine dinucleotide (NADH):ubiquinone oxidoreductase. This complex functions in the transfer of electrons from NADH to the respiratory chain, and ubiquinone is believed to be the immediate electron acceptor for the enzyme. Mutations in this gene cause Leigh syndrome due to mitochondrial complex I deficiency, a severe neurological disorder that results in bilaterally symmetrical necrotic lesions in subcortical brain regions. [provided by RefSeq, Jul 2008] |
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| Properties | |