| Protein Name | integrin subunit alpha V |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 3685 |
| Gene Symbol | ITGAV |
| UniProt | P06756 (ITAV_HUMAN), L7RXH0 (L7RXH0_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
374
Total Number of Articles : 439 |
Description |
integrin subunit alpha V |
| Gene Summary |
The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit. This subunit associates with beta 1, beta 3, beta 5, beta 6 and beta 8 subunits. The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. This integrin may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015] |
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