| Protein Name | integrin subunit alpha 5 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 3678 |
| Gene Symbol | ITGA5 |
| UniProt | P08648 (ITA5_HUMAN), B2R627 (B2R627_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
132
Total Number of Articles : 125 |
Description |
integrin subunit alpha 5 |
| Gene Summary |
The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 5 subunit. This subunit associates with the beta 1 subunit to form a fibronectin receptor. This integrin may promote tumor invasion, and higher expression of this gene may be correlated with shorter survival time in lung cancer patients. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015] |
| synonyms |
|
| Properties | |