Protein Name secreted protein acidic and cysteine rich
Organism Homo sapiens
Gene ID 6678
Gene Symbol


UniProt P09486 (SPRC_HUMAN)
Relationships Total Number of functionally related compound(s) : 206
Total Number of Articles : 341

secreted protein acidic and cysteine rich

Gene Summary

This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based on changes to cell shape which can promote tumor cell invasion. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2015]

  • basement-membrane protein 40
  • secreted protein, acidic, cysteine-rich (osteonectin)
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