Protein Name FAT atypical cadherin 1
Organism Homo sapiens
Gene ID 2195
Gene Symbol


UniProt Q14517 (FAT1_HUMAN)
Relationships Total Number of functionally related compound(s) : 404
Total Number of Articles : 615

FAT atypical cadherin 1

Gene Summary

This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and/or alternative promoter usage exist, but they have not been fully described. [provided by RefSeq, Jul 2008]

  • protocadherin Fat 1
  • FAT tumor suppressor 1
  • cadherin ME5
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