| Protein Name | high mobility group box 1 |
|---|---|
| Organism | Rattus norvegicus |
| Gene ID | 25459 |
| Gene Symbol | Hmgb1 |
| UniProt | P63159 (HMGB1_RAT), B4F758 (B4F758_RAT) |
| Relationships |
Total Number of functionally related compound(s) :
478
Total Number of Articles : 660 |
Description |
high mobility group box 1 |
| Gene Summary |
Enables several functions, including DNA binding activity; heparin binding activity; and signaling receptor binding activity. Involved in several processes, including positive regulation of cytokine production; psychomotor behavior; and response to bacterium. Acts upstream of or within several processes, including DNA geometric change; induction of positive chemotaxis; and positive regulation of mesenchymal cell proliferation. Located in cytosol; extracellular space; and membrane raft. Used to study artery disease (multiple); brain infarction; congestive heart failure; high grade glioma; and sciatic neuropathy. Biomarker of several diseases, including alcohol use disorder; colon adenocarcinoma; hydrocephalus; middle cerebral artery infarction; and obstructive jaundice. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Orthologous to human HMGB1 (high mobility group box 1). [provided by Alliance of Genome Resources, Jun 2025] |
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| Properties | |