| Protein Name | Transitional endoplasmic reticulum ATPase homolog 1 |
|---|---|
| Organism | Caenorhabditis elegans |
| Gene ID | 174624 |
| Gene Symbol | cdc-48.1 |
| UniProt | P54811 (TERA1_CAEEL) |
| Relationships |
Total Number of functionally related compound(s) :
6
Total Number of Articles : 4 |
Description |
Transitional endoplasmic reticulum ATPase homolog 1 |
| Gene Summary |
Enables ATP hydrolysis activity and identical protein binding activity. Involved in several processes, including ERAD pathway; positive regulation of mitotic cell cycle, embryonic; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Located in nucleoplasm and perinuclear region of cytoplasm. Part of VCP-NPL4-UFD1 AAA ATPase complex. Is expressed in several structures, including body wall musculature; germ line; and gonad. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 2Y; Paget's disease of bone; frontotemporal dementia and/or amyotrophic lateral sclerosis 6; inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 1; and inclusion body myositis. Orthologous to human VCP (valosin containing protein). [provided by Alliance of Genome Resources, Jul 2025] |
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| Properties | |