| Protein Name | thymoma viral proto-oncogene 2 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 11652 |
| Gene Symbol | Akt2 |
| UniProt | Q60823 (AKT2_MOUSE), Q3TY95 (Q3TY95_MOUSE), Q8CE74 (Q8CE74_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
150
Total Number of Articles : 151 |
Description |
thymoma viral proto-oncogene 2 |
| Gene Summary |
Enables protein serine/threonine kinase activity. Involved in negative regulation of PERK-mediated unfolded protein response and positive regulation of protein targeting to membrane. Acts upstream of or within several processes, including activation of GTPase activity; cellular response to high light intensity; and insulin receptor signaling pathway. Located in cell cortex and ruffle membrane. Is expressed in several structures, including central nervous system; genitourinary system; gut; hemolymphoid system gland; and integumental system. Used to study polycystic ovary syndrome and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in glucose metabolism disease (multiple); high grade glioma; and reproductive organ cancer (multiple). Orthologous to human AKT2 (AKT serine/threonine kinase 2). [provided by Alliance of Genome Resources, Jul 2025] |
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