| Protein Name | glycerol-3-phosphate dehydrogenase 1 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 2819 |
| Gene Symbol | GPD1 |
| UniProt | P21695 (GPDA_HUMAN), A0A024R138 (A0A024R138_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
37
Total Number of Articles : 29 |
Description |
glycerol-3-phosphate dehydrogenase 1 |
| Gene Summary |
This gene encodes a member of the NAD-dependent glycerol-3-phosphate dehydrogenase family. The encoded protein plays a critical role in carbohydrate and lipid metabolism by catalyzing the reversible conversion of dihydroxyacetone phosphate (DHAP) and reduced nicotine adenine dinucleotide (NADH) to glycerol-3-phosphate (G3P) and NAD+. The encoded cytosolic protein and mitochondrial glycerol-3-phosphate dehydrogenase also form a glycerol phosphate shuttle that facilitates the transfer of reducing equivalents from the cytosol to mitochondria. Mutations in this gene are a cause of transient infantile hypertriglyceridemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012] |
| synonyms |
|
| Properties | |